Abstract
From March, 1969, through June 1976, 108 porcine aortic xenograft valves were used for mitral or aortic valve replacement in 95 patients. This experience provides one of the longest follow-ups available for evaluation of the porcine bioprosthesis. The first fifteen valves were locally mounted on Cutter stents and preserved in buffered formalin. Subsequent valves were prepared by the Edwards and Hancock Companies with glutaraldehyde preservation. Oral anticoagulation was routinely used for the first 6 weeks following surgery. Hospital mortality was unrelated to the valve type. All but four of the surviving patients with formalin preserved valves have required reoperation because of valve failure. There have been two valve failures in the patients who received gluteraldehyde valves, but there have been no embolic or thrombotic complications. Late cardiac catheterization has shown hemodynamic results equal to or better than prosthetic valves. The continuing long-term results indicate that the porcine xenograft is the valve of choice for cardiac valve replacement.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Carpentier A., Deloche A., Relland J., Fabiani J. N., Forman J., Camilleri J. P., Soyer R., Dubost C. Six-year follow-up of glutaraldehyde-preserved heterografts. With particular reference to the treatment of congenital valve malformations. J Thorac Cardiovasc Surg. 1974 Nov;68(5):771–782. [PubMed] [Google Scholar]
- Carpentier A., Lemaigre G., Robert L., Carpentier S., Dubost C. Biological factors affecting long-term results of valvular heterografts. J Thorac Cardiovasc Surg. 1969 Oct;58(4):467–483. [PubMed] [Google Scholar]
- Ionescu M. I., Mashhour Y. A., Wooler G. H. Reconstructed heterograft aortic valves for human use: preparation and surgical implantation for mitral, aortic, and tricuspid replacement. Thorax. 1968 May;23(3):221–229. doi: 10.1136/thx.23.3.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ionescu M. I., Smith D. R., Sutherland T. W., Wooler G. H. Heart valve replacement with aortic heterografts. Follow-up study. Ann Thorac Surg. 1972 Jan;13(1):1–14. doi: 10.1016/s0003-4975(10)64806-0. [DOI] [PubMed] [Google Scholar]
- Ionescu M. I., Wooler G. H., Smith D. R., Grimshaw V. A. Mitral valve replacement with aortic heterografts in humans. Thorax. 1967 Jul;22(4):305–313. doi: 10.1136/thx.22.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ionescu M. I., Wooler G. H., Whitaker W., Smith D. R., Taylor S. H., Hargreaves M. D. Heart valve replacement with reinforced aortic heterografts. Technique and results. J Thorac Cardiovasc Surg. 1968 Sep;56(3):333–350. [PubMed] [Google Scholar]
- Reis R. L., Hancock W. D., Yarbrough J. W., Glancy D. L., Morrow A. G. The flexible stent. A new concept in the fabrication of tissue heart valve prostheses. J Thorac Cardiovasc Surg. 1971 Nov;62(5):683–passim. [PubMed] [Google Scholar]