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. 1979 Apr;189(4):503–508.

Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis.

J E Oscarson, H F Veen, J S Ross, R A Malt
PMCID: PMC1397257  PMID: 443906

Abstract

The effect of colonic hyperplasia produced by resection of the distal third of the small bowel (DSBR) on the development of chemical carcinogenesis of the colon by dimethylhydrazine (DMH) was tested in rats. For the most part the amounts of RNA and DNA in the small bowel were the same with the combined treatments as with either one alone; quantities of nucleic acids tended to increase only in transverse and distal colon. After 37 weeks the number of neoplasms per rat was increased six-fold by combining DSBR with DMH. Neoplasms were spread throughout the colon after combined treatment as opposed to the ascending colong after DMH alone. Postresectional hyperplasia appears to increase the incidence and distribution of colon tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Campbell R. L., Singh D. V., Nigro N. D. Importance of the fecal stream on the induction of colon tumors by azoxymethane in rats. Cancer Res. 1975 May;35(5):1369–1371. [PubMed] [Google Scholar]
  2. Chan P. C., Cohen L. A., Narisawa T., Weisburger J. H. Early effects of a single intrarectal dose of 1,2-dimethylhydrazine in mice. Cancer Res. 1976 Jan;36(1):13–17. [PubMed] [Google Scholar]
  3. Deschner E. E., Lipkin M. Proliferative patterns in colonic mucosa in familial polyposis. Cancer. 1975 Feb;35(2):413–418. doi: 10.1002/1097-0142(197502)35:2<413::aid-cncr2820350217>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  4. Farmer R. G., Hawk W. A., Turnbull R. B., Jr Carcinoma associated with mucosal ulcerative colitis, and with transmural colitis and enteritis (Crohn's disease). Cancer. 1971 Aug;28(2):289–292. doi: 10.1002/1097-0142(197108)28:2<289::aid-cncr2820280205>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  5. Garbutt J. T., Lack L., Tyor M. P. The enterohepatic circulation of bile salts in gastrointestinal disorders. Am J Med. 1971 Nov;51(5):627–636. doi: 10.1016/0002-9343(71)90286-5. [DOI] [PubMed] [Google Scholar]
  6. HINRICHS H. R., PETERSEN R. O., BASERGA R. INCORPORATION OF THYMIDINE INTO DNA OF MOUSE ORGANS. Arch Pathol. 1964 Sep;78:245–253. [PubMed] [Google Scholar]
  7. Lipkin M., Deschner E., Troncale F. Cell differentiation and the development of colonic neoplasms. Gastroenterology. 1970 Aug;59(2):303–307. [PubMed] [Google Scholar]
  8. Lipkin M. Proliferative changes in the colon. Am J Dig Dis. 1974 Nov;19(11):1029–1032. doi: 10.1007/BF01255785. [DOI] [PubMed] [Google Scholar]
  9. Maskens A. P. Histogenesis and growth pattern of 1,2-dimethylhydrazine-induced rat colon adenocarcinoma. Cancer Res. 1976 May;36(5):1585–1592. [PubMed] [Google Scholar]
  10. Morson B. C. Cancer in ulcerative colitis. Gut. 1966 Oct;7(5):425–426. doi: 10.1136/gut.7.5.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nigro N. D., Bhadrachari N., Chomchai C. A rat model for studying colonic cancer: effect of cholestyramine on induced tumors. Dis Colon Rectum. 1973 Nov-Dec;16(6):438–443. doi: 10.1007/BF02588866. [DOI] [PubMed] [Google Scholar]
  12. Nundy S., Malamud D., Obertop H., Sczerban J., Malt R. A. Onset of cell proliferation in the shortened gut. Colonic hyperplasia after ileal resection. Gastroenterology. 1977 Feb;72(2):263–266. [PubMed] [Google Scholar]
  13. Pozharisski K. M. The significance of nonspecific injury for colon carcinogenesis in rats. Cancer Res. 1975 Dec;35(12):3824–3830. [PubMed] [Google Scholar]
  14. Reddy B. S., Narisawa T., Maronpot R., Weisburger J. H., Wynder E. L. Animal models for the study of dietary factors and cancer of the large bowel. Cancer Res. 1975 Nov;35(11 Pt 2):3421–3426. [PubMed] [Google Scholar]
  15. Richards T. C. Early changes in the dynamics of crypt cell populations in mouse colon following administration of 1,2-dimethylhydrazine. Cancer Res. 1977 Jun;37(6):1680–1685. [PubMed] [Google Scholar]
  16. SCOTT J. F., FRACCASTORO A. P., TAFT E. B. Studies in histochemistry. I. Determination of nucleic acids in microgram amounts of tissue. J Histochem Cytochem. 1956 Jan;4(1):1–10. doi: 10.1177/4.1.1. [DOI] [PubMed] [Google Scholar]
  17. Springer P., Springer J., Oehlert W. Die Vorstufen des 1,2-Dimethylhydrazin-induzierten Dick- und Dünndarmcarcinoms der Ratte. Z Krebsforsch. 1970;74(3):236–240. [PubMed] [Google Scholar]
  18. Thurnherr N., Deschner E. E., Stonehill E. H., Lipkin M. Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine. Cancer Res. 1973 May;33(5):940–945. [PubMed] [Google Scholar]
  19. Tutton P. J., Barkla D. H. Cell proliferation in the descending colon of dimethylhydrazine treated rats and in dimethylhydrazine induced adenocarcinomata. Virchows Arch B Cell Pathol. 1976 Aug 11;21(2):147–160. doi: 10.1007/BF02899151. [DOI] [PubMed] [Google Scholar]
  20. Ward J. M. Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab Invest. 1974 Apr;30(4):505–513. [PubMed] [Google Scholar]
  21. Weisburger J. H. Chemical carcinogens and their mode of action in colonic neoplasia. Dis Colon Rectum. 1973 Nov-Dec;16(6):431–437. doi: 10.1007/BF02588865. [DOI] [PubMed] [Google Scholar]
  22. Weisburger J. H. Colon carcinogens: their metabolism and mode of action. Cancer. 1971 Jul;28(1):60–70. doi: 10.1002/1097-0142(197107)28:1<60::aid-cncr2820280113>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  23. Williamson R. C., Bauer F. L., Oscarson J. E., Ross J. S., Malt R. A. Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel. Cancer Res. 1978 Oct;38(10):3212–3217. [PubMed] [Google Scholar]
  24. Wittig G., Wildner G. P., Ziebarth D. Der Einfluss der Ingesta auf die Kanzerisierung des Rattendarms durch Dimethylhydrazin. Arch Geschwulstforsch. 1971;37(2):105–115. [PubMed] [Google Scholar]

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