Skip to main content
PMC home page
Gut logoLink to Gut
. 1970 Mar;11(3):197–205. doi: 10.1136/gut.11.3.197

Two cases of `pancreatic cholera' with features of peptide-secreting adenomatosis of the pancreas

W Sircus, P W Brunt, R J Walker, W P Small, C W A Falconer, Christine G Thomson
PMCID: PMC1411440  PMID: 4316433

Abstract

The clinical data are presented of two women with profound metabolic upset from exceptional water and electrolyte losses in diarrhoea. One had an islet-cell adenoma of the pancreas and the other abnormal islets. Gastric and pancreatic function were abnormal in both, consistent with the subsequent demonstration of a pancreatic and choleretic secretagogue in the tumour tissue and pancreatic and gastric secretagogues in circulating blood (Cleator, Thomson, Sircus, and Coombes, 1970).

Full text

PDF
200

Images in this article

201Fig. 7
on p.201

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CREAMER B. VARIATIONS IN SMALL-INTESTINAL VILLOUS SHAPE AND MUCOSAL DYNAMICS. Br Med J. 1964 Nov 28;2(5421):1371–1373. doi: 10.1136/bmj.2.5421.1371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. GREENLEE H. B., LONGHI E. H., GUERRERO J. D., NELSEN T. S., EL-BEDRI A. L., DRAGSTEDT L. R. Inhibitory effect of pancreatic secretin on gastric secretion. Am J Physiol. 1957 Sep;190(3):396–402. doi: 10.1152/ajplegacy.1957.190.3.396. [DOI] [PubMed] [Google Scholar]
  3. Gardner J. D., Cerda J. J. In vitro inhibition of intestinal fluid and electrolyte transfer by a non-beta islet cell tumor. Proc Soc Exp Biol Med. 1966 Nov;123(2):361–364. doi: 10.3181/00379727-123-31488. [DOI] [PubMed] [Google Scholar]
  4. Goulon M., Rapin M., Charleux H., Baguet J. C., Kuntziger H., Nouailhat F., Barois A., Breteau M. Diarrhée aqueuse et hypokaliémie associées à une tumeur langerhansienne non insulino-secrétante. A propos d'un cas avec guérison immédiate et définitive de la diarrhée par exérèse tumorale. Discussion nosologique de ce syndrome avec celui de Zollinger et Ellison. Bull Mem Soc Med Hop Paris. 1966 May 27;117(7):623–646. [PubMed] [Google Scholar]
  5. Grossman M. I. Treatment of duodenal ulcer with secretin: a speculative proposal. Gastroenterology. 1966 Jun;50(6):912–913. [PubMed] [Google Scholar]
  6. HINDLE W., MCBRIEN D. J., CREAMER B. WATERY DIARRHOEA AND AN ISLET CELL TUMOUR. Gut. 1964 Aug;5:359–362. doi: 10.1136/gut.5.4.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. JAMES A. H. GASTRIC EPITHELIUM IN THE DUODENUM. Gut. 1964 Aug;5:285–294. doi: 10.1136/gut.5.4.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jesseph J. E., Moore F. T., Endahl G., Passi R. B. Peptic ulceration and enteritis. A differential diagnosis. Am J Surg. 1967 Feb;113(2):188–193. doi: 10.1016/0002-9610(67)90220-6. [DOI] [PubMed] [Google Scholar]
  9. Levin M. E. Endocrine syndromes associated with pancreatic islet cell tumors. Med Clin North Am. 1968 Mar;52(2):295–312. [PubMed] [Google Scholar]
  10. Mansbach C. M., 2nd, Wilkins R. M., Dobbins W. O., Tyor M. P. Intestinal mucosal function and structure in the steatorrhea of Zollinger-Ellison syndrome. Arch Intern Med. 1968 Jun;121(6):487–494. [PubMed] [Google Scholar]
  11. Marks I. N., Bank S., Louw J. H. Islet cell tumor of the pancreas with reversible watery diarrhea and achylorhydraia. Gastroenterology. 1967 Apr;52(4):695–708. [PubMed] [Google Scholar]
  12. PARKINS R. A. Severe watery diarrhoea and potassium depletion associated with an islet-cell tumour of pancreas. Br Med J. 1961 Aug 5;2(5248):356–357. doi: 10.1136/bmj.2.5248.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. PRIEST W. M., ALEXANDER M. K. Isletcell tumour of the pancreas with peptic ulceration, diarrhoea, and hypokalaemia. Lancet. 1957 Dec 7;273(7006):1145–1147. doi: 10.1016/s0140-6736(57)92051-2. [DOI] [PubMed] [Google Scholar]
  14. Paloyan D., Paloyan E., Worobec R., Ernst K., Deininger E., Harper P. V. Serum glucagon levels in experimental acute pancreatitis in the dog. Surg Forum. 1966;17:348–349. [PubMed] [Google Scholar]
  15. SINGLETON J. W., KERN F., Jr, WADDELL W. R. DIARRHEA AND PANCREATIC ISLET CELL TUMOR: REPORT OF A CASE WITH A SEVERE JEJUNAL MUCOSAL LESION. Gastroenterology. 1965 Aug;49:197–208. [PubMed] [Google Scholar]
  16. SIRCUS W. PROLONGED AUGMENTATION OF THE MAXIMAL SECRETORY RESPONSES OF CANINE GASTRIC POUCHES BY CHRONIC OBSTRUCTION: A PRELIMINARY REPORT AND A HYPOTHESIS. Am J Dig Dis. 1965 Jun;10:499–505. doi: 10.1007/BF02233042. [DOI] [PubMed] [Google Scholar]
  17. Shimoda S. S., Saunders D. R., Rubin C. E. The Zollinger-Ellison syndrome with steatorrhea. II. The mechanism of fat and vitamin B 12 malabsorption. Gastroenterology. 1968 Dec;55(6):705–723. [PubMed] [Google Scholar]
  18. Sircus W., Brunt P. W., Walker R. J., Small W. P., Falconer C. W., Thomson C. G. Two cases of "pancreatic cholera" with features of peptide-secreting adenomatosis of the pancreas. Gut. 1970 Mar;11(3):197–205. doi: 10.1136/gut.11.3.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sircus W. Peptide-seceting adenomata with special reference to the Zollinger-Ellison syndrome. Postgrad Med J. 1968 Sep;44(515):742–748. doi: 10.1136/pgmj.44.515.742. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sircus W. Peptide-secreting tumours with special reference to the pancreas. Gut. 1969 Jul;10(7):506–515. doi: 10.1136/gut.10.7.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. ZOLLINGER R. M., ELLISON E. H. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8. [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES