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. 1981 Apr;22(4):295–300. doi: 10.1136/gut.22.4.295

The liver in siblings of patients with Indian childhood cirrhosis: a light and electron microscopic study.

N C Nayak, N Marwaha, V Kalra, S Roy, O P Ghai
PMCID: PMC1419158  PMID: 7239321

Abstract

Liver biopsies from 29 siblings of patients with Indian childhood cirrhosis (ICC) and from two age-matched controls were examined by routine light and transmission electron microscopy. Histochemical stainings for copper and copper-binding protein were also carried out. The mild and non-specific structural alterations that were observed did not differ from those seen in control livers, even though a slight to moderate excess of copper and copper-binding protein was demonstrated in the majority. Aggregates of microtubules seen in some siblings, as well as in control livers, may indicate the preconditions for development of Mallory hyaline. It is possible that these features suggest a susceptibility for the development of ICC but not early disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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