Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1992 Aug;76(4):668–670.

Lymphocytes bearing the gamma delta T-cell receptor in acute toxoplasmosis.

F Scalise 1, R Gerli 1, G Castellucci 1, F Spinozzi 1, G M Fabietti 1, S Crupi 1, L Sensi 1, R Britta 1, R Vaccaro 1, A Bertotto 1
PMCID: PMC1421574  PMID: 1398756

Abstract

Although the relative and absolute numbers of CD3+ cells (T lymphocytes) were similar in eight children with acquired Toxoplasma gondii infection and 10 uninfected age- and sex-matched healthy controls, the proportion of cells bearing the gamma delta T-cell receptor was significantly higher in the subjects with acute toxoplasmosis. The great majority of gamma delta T cells from the infected patients expressed covalently bound gamma delta chains on their surface, i.e. were BB3+ lymphocytes. Since the gamma delta T-cell subsets exert both restricted and unrestricted major histocompatibility complex cytotoxicity, further research is needed to elucidate the role of gamma delta T cells in the control of this coccidian protozoan infection.

Full text

PDF
670

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Born W. K., Harshan K., Modlin R. L., O'Brien R. L. The role of gamma delta T lymphocytes in infection. Curr Opin Immunol. 1991 Aug;3(4):455–459. doi: 10.1016/0952-7915(91)90002-i. [DOI] [PubMed] [Google Scholar]
  2. Brenner M. B., Strominger J. L., Krangel M. S. The gamma delta T cell receptor. Adv Immunol. 1988;43:133–192. [PubMed] [Google Scholar]
  3. Casorati G., De Libero G., Lanzavecchia A., Migone N. Molecular analysis of human gamma/delta+ clones from thymus and peripheral blood. J Exp Med. 1989 Nov 1;170(5):1521–1535. doi: 10.1084/jem.170.5.1521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. De Libero G., Casorati G., Giachino C., Carbonara C., Migone N., Matzinger P., Lanzavecchia A. Selection by two powerful antigens may account for the presence of the major population of human peripheral gamma/delta T cells. J Exp Med. 1991 Jun 1;173(6):1311–1322. doi: 10.1084/jem.173.6.1311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gerli R., Bertotto A., Rambotti P., Barbieri P., Ciompi M. L., Bombardieri S. T cell immunoregulation in rheumatoid synovitis. Arthritis Rheum. 1988 Aug;31(8):1075–1076. doi: 10.1002/art.1780310823. [DOI] [PubMed] [Google Scholar]
  6. Inoue T., Yoshikai Y., Matsuzaki G., Nomoto K. Early appearing gamma/delta-bearing T cells during infection with Calmétte Guérin bacillus. J Immunol. 1991 Apr 15;146(8):2754–2762. [PubMed] [Google Scholar]
  7. Kabelitz D., Bender A., Prospero T., Wesselborg S., Janssen O., Pechhold K. The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells. J Exp Med. 1991 Jun 1;173(6):1331–1338. doi: 10.1084/jem.173.6.1331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Minoprio P., Bandeira A., Pereira P., Mota Santos T., Coutinho A. Preferential expansion of Ly-1 B and CD4- CD8- T cells in the polyclonal lymphocyte responses to murine T. cruzi infection. Int Immunol. 1989;1(2):176–184. doi: 10.1093/intimm/1.2.176. [DOI] [PubMed] [Google Scholar]
  9. Miyawaki T., Kasahara Y., Taga K., Yachie A., Taniguchi N. Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta+ lymphocytes. J Exp Med. 1990 May 1;171(5):1833–1838. doi: 10.1084/jem.171.5.1833. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ohga S., Yoshikai Y., Takeda Y., Hiromatsu K., Nomoto K. Sequential appearance of gamma/delta- and alpha/beta-bearing T cells in the peritoneal cavity during an i.p. infection with Listeria monocytogenes. Eur J Immunol. 1990 Mar;20(3):533–538. doi: 10.1002/eji.1830200311. [DOI] [PubMed] [Google Scholar]
  11. Parker C. M., Groh V., Band H., Porcelli S. A., Morita C., Fabbi M., Glass D., Strominger J. L., Brenner M. B. Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire. J Exp Med. 1990 May 1;171(5):1597–1612. doi: 10.1084/jem.171.5.1597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Roberts K., Yokoyama W. M., Kehn P. J., Shevach E. M. The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells. J Exp Med. 1991 Jan 1;173(1):231–240. doi: 10.1084/jem.173.1.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sturm E., Braakman E., Bontrop R. E., Chuchana P., Van de Griend R. J., Koning F., Lefranc M. P., Bolhuis R. L. Coordinated V gamma and V delta gene segment rearrangements in human T cell receptor gamma/delta+ lymphocytes. Eur J Immunol. 1989 Jul;19(7):1261–1265. doi: 10.1002/eji.1830190717. [DOI] [PubMed] [Google Scholar]
  14. Triebel F., Hercend T. Subpopulations of human peripheral T gamma delta lymphocytes. Immunol Today. 1989 Jun;10(6):186–188. doi: 10.1016/0167-5699(89)90321-6. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES