Abstract
The catabolism of 131I-labelled rabbit and human albumin and γ globulin has been studied in baby rabbits from the 1st to the 6th week after birth. The half-lives, based in plasma concentrations corrected for growth, were approximately constant throughout this period, and were as follows: rabbit albumin and human albumin, about 6 days; rabbit γ globulin and human γ globulin, 12–14 days. Until the age of about 3 weeks, renal excretion of iodide was very inefficient. Consequently free 131I accumulated in the stomachs, and the whole body radio-activity greatly exceeded that due to retained labelled protein.
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