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. 1961 Oct;4(4):380–387.

The Metabolism of Homologous and Heterologous Serum Proteins in Baby Rabbits

J H Humphrey
PMCID: PMC1424114  PMID: 14449976

Abstract

The catabolism of 131I-labelled rabbit and human albumin and γ globulin has been studied in baby rabbits from the 1st to the 6th week after birth. The half-lives, based in plasma concentrations corrected for growth, were approximately constant throughout this period, and were as follows: rabbit albumin and human albumin, about 6 days; rabbit γ globulin and human γ globulin, 12–14 days. Until the age of about 3 weeks, renal excretion of iodide was very inefficient. Consequently free 131I accumulated in the stomachs, and the whole body radio-activity greatly exceeded that due to retained labelled protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BANGHAM D. R., TERRY R. J. The survival of globulins absorbed from the gut in suckling rats. Biochem J. 1957 Aug;66(4):584–587. doi: 10.1042/bj0660584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DEICHMILLER M. P., DIXON F. J. The metabolism of serum proteins in neonatal rabbits. J Gen Physiol. 1960 Jul;43:1047–1059. doi: 10.1085/jgp.43.6.1047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. GEDIN H. I., PORATH J. Studies of zone electrophoresis in vertical columns. II. Zone electrophoresis of serum proteins. Biochim Biophys Acta. 1957 Oct;26(1):159–169. doi: 10.1016/0006-3002(57)90067-7. [DOI] [PubMed] [Google Scholar]
  4. MARTIN C. M., GORDON R. S., FELTS W. R., MCCULLOUGH N. B. Studies on gamma globulin. I. Distribution and metabolism of antibodies and gamma globulin in hypogammaglobulinemic patients. J Lab Clin Med. 1957 Apr;49(4):607–616. [PubMed] [Google Scholar]
  5. McFARLANE A. S. Efficient trace-labelling of proteins with iodine. Nature. 1958 Jul 5;182(4627):53–53. doi: 10.1038/182053a0. [DOI] [PubMed] [Google Scholar]
  6. McFARLANE A. S. The behavior of I 131-labeled plasma proteins in vivo. Ann N Y Acad Sci. 1957 Aug 30;70(1):19–25. doi: 10.1111/j.1749-6632.1957.tb35374.x. [DOI] [PubMed] [Google Scholar]
  7. SMITH R. T., BRIDGES R. A. Immunological unresponsiveness in rabbits produced by neonatal injection of defined antigens. J Exp Med. 1958 Aug 1;108(2):227–250. doi: 10.1084/jem.108.2.227. [DOI] [PMC free article] [PubMed] [Google Scholar]

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