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. 1984 Apr;45(4):841–849. doi: 10.1016/S0006-3495(84)84228-9

Impulse responses of automaticity in the Purkinje fiber.

T R Chay, Y S Lee
PMCID: PMC1434904  PMID: 6722270

Abstract

We examined the effects of brief current pulses on the pacemaker oscillations of the Purkinje fiber using the model of McAllister , Noble, and Tsien (1975. J. Physiol. [Lond.]. 251:1-57). This model was used to construct phase-response curves for brief electric stimuli to find "black holes," where rhythmic activity of the Purkinje fiber ceases. In our computer simulation, a brief current stimulus of the right magnitude and timing annihilated oscillations in membrane potential. The model also revealed a sequence of alternating periodic and chaotic regimes as the strength of a steady bias current is varied. We compared the results of our computer simulations with experimental work on Purkinje fibers and pointed out the importance of modeling results of this kind for understanding cardiac arrhythmias.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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