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. 1974 Dec;27(6):989–1007.

Immunological disease induced by injecting F1 lymphoid cells into certain parental strains

Elizabeth Simpson, Susan O'Hopp, M Harrison, D Mosier, K Melief, H Cantor
PMCID: PMC1445694  PMID: 4156027

Abstract

Injection of neonatal Balb/c or C57Bl/6 mice with C57Bl/6 x Balb/c)F1 lymphoid cells leads to transient chimerism and runting, and to splenomegaly, deficient T-cell function and a gradual replacement of lymphoid organs with abnormal reticular cells. Activated MuLV can be isolated from such mice. It is proposed that either graft-versus-host or host-versus-graft allogeneic reactivity activates endogenous MuLV virus, which then causes functional and morphological abnormalities in the lymphoid organs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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