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. 1984 Jul;52(3):389–394.

Role of maternal immunity in the protection of newborn ferrets against infection with a virulent influenza virus.

R H Husseini, C Sweet, H Overton, H Smith
PMCID: PMC1454495  PMID: 6745992

Abstract

Intranasal infection of newborn ferrets with a virulent strain of influenza virus invariably resulted in their deaths following virus replication to high titre in both lung and nasal turbinates (Collie et al., 1980). However, a similar challenge of newborn ferrets born to mothers immunized by infection with virulent or attenuated viruses resulted in complete protection; no virus replicated in their lungs and little or no virus was isolated from their nasal turbinates. Protection appeared to be antibody-mediated since it was sub-type-specific and milk-derived since newborn ferrets born to non-immune mothers but fostered onto immune mothers exhibited a similar level of protection to neonates born to and suckled by immune mothers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barber W. H., Small P. A., Jr Local and systemic immunity to influenza infections in ferrets. Infect Immun. 1978 Jul;21(1):221–228. doi: 10.1128/iai.21.1.221-228.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Basarab O., Smith H. Quantitative studies on the tissue localization of influenza virus in ferrets after intranasal and intravenous or intracardial inoculation. Br J Exp Pathol. 1969 Dec;50(6):612–618. [PMC free article] [PubMed] [Google Scholar]
  3. Coates D. M., Husseini R. H., Collie M. H., Sweet C., Smith H. The role of cellular susceptibility in the declining severity of respiratory influenza of ferrets with age. Br J Exp Pathol. 1984 Feb;65(1):29–39. [PMC free article] [PubMed] [Google Scholar]
  4. Collie M. H., Rushton D. I., Sweet C., Smith H. Studies of influenza virus infection in newborn ferrets. J Med Microbiol. 1980 Nov;13(4):561–571. doi: 10.1099/00222615-13-4-561. [DOI] [PubMed] [Google Scholar]
  5. Downham M. A., Scott R., Sims D. G., Webb J. K., Gardner P. S. Breast-feeding protects against respiratory syncytial virus infections. Br Med J. 1976 Jul 31;2(6030):274–276. doi: 10.1136/bmj.2.6030.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Glezen W. P. Considerations of the risk of influenza in children and indications for prophylaxis. Rev Infect Dis. 1980 May-Jun;2(3):408–420. doi: 10.1093/clinids/2.3.408. [DOI] [PubMed] [Google Scholar]
  7. Husseini R. H., Collie M. H., Rushton D. I., Sweet C., Smith H. The role of naturally-acquired bacterial infection in influenza-related death in neonatal ferrets. Br J Exp Pathol. 1983 Oct;64(5):559–569. [PMC free article] [PubMed] [Google Scholar]
  8. Kim H. W., Brandt C. D., Arrobio J. O., Murphy B., Chanock R. M., Parrott R. H. Influenza A and B virus infection in infants and young children during the years 1957-1976. Am J Epidemiol. 1979 Apr;109(4):464–479. doi: 10.1093/oxfordjournals.aje.a112704. [DOI] [PubMed] [Google Scholar]
  9. Laraya-Cuasay L. R., DeForest A., Huff D., Lischner H., Huang N. N. Chronic pulmonary complications of early influenza virus infection in children. Am Rev Respir Dis. 1977 Oct;116(4):617–625. doi: 10.1164/arrd.1977.116.4.617. [DOI] [PubMed] [Google Scholar]
  10. MacKenzie J. S., Houghton M. Influenza infections during pregnancy: association with congenital malformations and with subsequent neoplasms in children, and potential hazards of live virus vaccines. Bacteriol Rev. 1974 Dec;38(4):356–370. doi: 10.1128/br.38.4.356-370.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Matsuyama T., Sweet C., Collie M. H., Smith H. Aspects of virulence in ferrets exhibited by influenza virus recombinants of known genetic constitution. J Infect Dis. 1980 Mar;141(3):351–361. doi: 10.1093/infdis/141.3.351. [DOI] [PubMed] [Google Scholar]
  12. Murphy T. F., Henderson F. W., Clyde W. A., Jr, Collier A. M., Denny F. W. Pneumonia: an eleven-year study in a pediatric practice. Am J Epidemiol. 1981 Jan;113(1):12–21. doi: 10.1093/oxfordjournals.aje.a113061. [DOI] [PubMed] [Google Scholar]
  13. Paine R., Coble R. J. Breast-feeding and infant health in a rural US community. Am J Dis Child. 1982 Jan;136(1):36–38. doi: 10.1001/archpedi.1982.03970370038009. [DOI] [PubMed] [Google Scholar]
  14. Paisley J. W., Bruhn F. W., Lauer B. A., McIntosh K. Type A2 influenza viral infections in children. Am J Dis Child. 1978 Jan;132(1):34–36. doi: 10.1001/archpedi.1978.02120260036007. [DOI] [PubMed] [Google Scholar]
  15. Puck J. M., Glezen W. P., Frank A. L., Six H. R. Protection of infants from infection with influenza A virus by transplacentally acquired antibody. J Infect Dis. 1980 Dec;142(6):844–849. doi: 10.1093/infdis/142.6.844. [DOI] [PubMed] [Google Scholar]
  16. Renshaw H. W. Influence of antibody-mediated immune suppression on clinical, viral, and immune responses to swine influenza infection. Am J Vet Res. 1975 Jan;36(1):5–13. [PubMed] [Google Scholar]
  17. Reuman P. D., Paganini C. M., Ayoub E. M., Small P. A., Jr Maternal-infant transfer of influenza-specific immunity in the mouse. J Immunol. 1983 Feb;130(2):932–936. [PubMed] [Google Scholar]
  18. Suffin S. C., Prince G. A., Muck K. B., Porter D. D. Immunoprophylaxis of respiratory syncytial virus infection in the infant ferret. J Immunol. 1979 Jul;123(1):10–14. [PubMed] [Google Scholar]
  19. Sumaya C. V., Gibbs R. S. Immunization of pregnant women with influenza A/New Jersey/76 virus vaccine: reactogenicity and immunogenicity in mother and infant. J Infect Dis. 1979 Aug;140(2):141–146. doi: 10.1093/infdis/140.2.141. [DOI] [PubMed] [Google Scholar]
  20. Sweet C., Smith H. Pathogenicity of influenza virus. Microbiol Rev. 1980 Jun;44(2):303–330. doi: 10.1128/mr.44.2.303-330.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sweet C., Stephen J., Smith H. Purification of influenza viruses using disulphide-linked immunosorbents derived from rabbit antibody. Immunochemistry. 1974 Jun;11(6):295–304. doi: 10.1016/0019-2791(74)90365-6. [DOI] [PubMed] [Google Scholar]
  22. Sweet C., Stephen J., Smith H. The behaviour of antigenically related influenza viruses of differing virulence on disulphide-linked immunosorbents. Immunochemistry. 1974 Dec;11(12):823–826. doi: 10.1016/0019-2791(74)90304-8. [DOI] [PubMed] [Google Scholar]
  23. Sweet C., Toms G. L., Smith H. The pregnant ferret as a model for studying the congenital effects of influenza virus infection in utero: infection of foetal tissues in organ culture and in vivo. Br J Exp Pathol. 1977 Apr;58(2):113–123. [PMC free article] [PubMed] [Google Scholar]

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