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. 1970 Sep;19(3):457–464.

Rate of antigen catabolism and immunogenicity of [131I]BGG in mice

II. Immunogenicity of [131I]BGG and adjuvant action after alteration of the metabolic rate by various means

J M Stark
PMCID: PMC1455686  PMID: 5471829

Abstract

Elimination of [131I]BGG was observed after attempts had been made to accelerate protein catabolism by thyroxine at three dose levels. Immune-type elimination did not result during primary exposure but treatment with the hormone predisposed to immune elimination on second and tertiary exposure to antigen, even at dosages of the hormone not obviously accelerating protein catabolism.

Vitamin A did not require (thyroid) accelerated catabolism to initiate an immune response. It did not itself influence the preimmune rate of elimination of antigen.

Raised ambient temperature or a high carbohydrate diet slowed down catabolism. Mice with slow catabolism formed less antibody against BGG after the use of mycobacterial adjuvants than did controls. These adjuvants are maximally effective when antigen is being catabolized rapidly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DRESSER D. W. Elimination of 131-I-labelled protein antigens from the circulation of the mouse. Immunology. 1960 Oct;3:289–295. [PMC free article] [PubMed] [Google Scholar]
  2. Dresser D. W. Adjuvanticity of vitamin A. Nature. 1968 Feb 10;217(5128):527–529. doi: 10.1038/217527a0. [DOI] [PubMed] [Google Scholar]
  3. Dresser D. W. Specific inhibition of antibody production. IV. Standardization of the antigen-elimination test; immunological paralysis of mice previously immunized. Immunology. 1965 Sep;9(3):261–273. [PMC free article] [PubMed] [Google Scholar]
  4. ERNSTROM U., GYLLENSTEN L. The histologic picture in thyroxin-induced lymphatic hyperplasia: a quantitative examination on guinea pig. Acta Pathol Microbiol Scand. 1959;47:243–255. doi: 10.1111/j.1699-0463.1959.tb03712.x. [DOI] [PubMed] [Google Scholar]
  5. Gall D. The adjuvant activity of aliphatic nitrogenous bases. Immunology. 1966 Oct;11(4):369–386. [PMC free article] [PubMed] [Google Scholar]
  6. Hardy D., Rowley D. The production of antibody to bovine serum albumin in unresponsive (Sobey) mice. Immunology. 1968 Mar;14(3):401–407. [PMC free article] [PubMed] [Google Scholar]
  7. LONG D. A., SHEWELL J. The influence of the thyroid gland on the production of antitoxin in the guinea-pig. Br J Exp Pathol. 1955 Aug;36(4):351–356. [PMC free article] [PubMed] [Google Scholar]
  8. Pennycuik P. R. A comparison of the effects of a variety of factors on the metabolic rate of the mouse. Aust J Exp Biol Med Sci. 1967 Aug;45(4):331–346. doi: 10.1038/icb.1967.33. [DOI] [PubMed] [Google Scholar]
  9. Stark J. M. Rate of antigen catabolism and immunogenicity of [131-I]BGG in mice. I. Action of mycobacterial adjuvants. Immunology. 1970 Sep;19(3):449–456. [PMC free article] [PubMed] [Google Scholar]
  10. White R. G. Antigens and adjuvants. Proc R Soc Med. 1968 Jan;61(1):1–6. [PMC free article] [PubMed] [Google Scholar]

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