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. 1970 Sep;19(3):457–464.

Rate of antigen catabolism and immunogenicity of [131I]BGG in mice

II. Immunogenicity of [131I]BGG and adjuvant action after alteration of the metabolic rate by various means

J M Stark
PMCID: PMC1455686  PMID: 5471829

Abstract

Elimination of [131I]BGG was observed after attempts had been made to accelerate protein catabolism by thyroxine at three dose levels. Immune-type elimination did not result during primary exposure but treatment with the hormone predisposed to immune elimination on second and tertiary exposure to antigen, even at dosages of the hormone not obviously accelerating protein catabolism.

Vitamin A did not require (thyroid) accelerated catabolism to initiate an immune response. It did not itself influence the preimmune rate of elimination of antigen.

Raised ambient temperature or a high carbohydrate diet slowed down catabolism. Mice with slow catabolism formed less antibody against BGG after the use of mycobacterial adjuvants than did controls. These adjuvants are maximally effective when antigen is being catabolized rapidly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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