Abstract
Two series of experiments are described in which elimination of [131I]BGG is observed in CBA mice treated with mycobacterial adjuvants. Neither mycobacteria in oil nor Wax D in oil induced immune-type elimination in the first series where control mice catabolized the antigen relatively slowly (mean half-lives of 4.38 and 5.0 days). In a second series where control mice showed faster catabolism (mean half-lives 3.82 and 2.96 days) the adjuvants did induce immune elimination. It was found also that such adjuvants invariably accelerated the elimination rate in the pre-immune period of elimination.
Porton White mice eliminated the antigen rapidly and even mice not given adjuvant frequently gave a secondary immune response on a further exposure to antigen.
The results suggest that increases in the rate of antigen catabolism contribute to adjuvant activity in this model.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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