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. 1970 Aug;19(2):329–342.

The interaction of normal lymphocytes and cells from lymphoid cell lines

I. The nature of the activation process

D A Hardy, Stella Knight, N R Ling
PMCID: PMC1455751  PMID: 4990403

Abstract

Human peripheral lymphocytes from all donors tested were mitotically activated when cultured in the presence of X-irradiated cells from continuously cultivated lymphoid cell lines (LCL). X-irradiated cells from LCL originating from normal individuals were effective as well as those of Burkitt's tumour origin and cells from LCL reported to be free of herpes-like virus were as effective as those reported to contain virus. The activation was of much greater intensity than the normal mixed lymphocyte reaction but occurred over a similar culture period. The reaction occurred only under conditions permitting direct cell contact between the two populations of cells. Most stimulation was obtained with viable X-irradiated LCL cells. Disrupted LCL cells were ineffective.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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