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. 1979 Sep;38(1):57–62.

Restricted heterogeneity of antibody synthesized by T-cell deprived mice.

M J Doenhoff, R Musallam, K D Keeler, D W Dresser
PMCID: PMC1457899  PMID: 315917

Abstract

Mice which had been thymectomized and injected with anti-thymocyte serum to remove long-lived recirculating T cells, initially failed to produce haemagglutinating and haemolysing antibody after injection of sheep erythrocytes. After six fortnightly injections of heterologous erythrocytes, however, haemolysin titres in the T-cell deprived mice were comparable to those in similarly challenged but immunologically intact animals. Isoelectric focusing of these sera indicated that the anti-sheep erythrocyte antibody eventually synthesized by the T-cell deprived mice was less heterogeneous than antibodies found in the sera of control mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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