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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1984 Aug;18(2):258–262. doi: 10.1111/j.1365-2125.1984.tb02466.x

The stimulatory effects of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine on human sperm motility.

C S Jiang, S A Kilfeather, R M Pearson, P Turner
PMCID: PMC1463533  PMID: 6207849

Abstract

The potencies of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine (IBMX) in stimulating sperm motility have been compared, and we have found IBMX to be significantly more potent than the other three compounds, which did not exhibit significant differences in potency from each other.

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Selected References

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  1. Aitken R. J., Best F., Richardson D. W., Schats R., Simm G. Influence of caffeine on movement characteristics, fertilizing capacity and ability to penetrate cervical mucus of human spermatozoa. J Reprod Fertil. 1983 Jan;67(1):19–27. doi: 10.1530/jrf.0.0670019. [DOI] [PubMed] [Google Scholar]
  2. Bergstrand H. Phosphodiesterase inhibition and theophylline. Eur J Respir Dis Suppl. 1980;109:37–44. [PubMed] [Google Scholar]
  3. Davis C. W., Kuo J. F. Differential effects of cyclic nucleotides and their analogs and various agents on cyclic GMP-specific and cyclic AMP-specific phosphodiesterases purified from guinea pig lung. Biochem Pharmacol. 1978 Jan 1;27(1):89–95. doi: 10.1016/0006-2952(78)90261-7. [DOI] [PubMed] [Google Scholar]
  4. De Turner E., Aparicio N. J., Turner D., Schwarzstein L. Effect of two phosphodiesterase inhibitors, cyclic adenosine 3':5'-monophosphate, and a beta-blocking agent on human sperm motility. Fertil Steril. 1978 Mar;29(3):328–331. doi: 10.1016/s0015-0282(16)43161-4. [DOI] [PubMed] [Google Scholar]
  5. Fredholm B. B., Brodin K., Strandberg K. On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors. Acta Pharmacol Toxicol (Copenh) 1979 Nov;45(5):336–344. doi: 10.1111/j.1600-0773.1979.tb02402.x. [DOI] [PubMed] [Google Scholar]
  6. Fujii T., Nishimura H. Reduction in frequency of fetopathic effects of caffeine in mice by pretreatment with propranolol. Teratology. 1974 Oct;10(2):149–152. doi: 10.1002/tera.1420100210. [DOI] [PubMed] [Google Scholar]
  7. Garbers D. L., Kopf G. S. The regulation of spermatozoa by calcium cyclic nucleotides. Adv Cyclic Nucleotide Res. 1980;13:251–306. [PubMed] [Google Scholar]
  8. Garbers D., First N. L., Lardy H. A. The stimulation of bovine epididymal sperm metabolism by cyclic nucleotide phosphodiesterase inhibitors. Biol Reprod. 1973 Jun;8(5):589–598. doi: 10.1093/biolreprod/8.5.589. [DOI] [PubMed] [Google Scholar]
  9. Glass W. F., 2nd, Moore J. B., Jr Inhibition of human lung cyclic GMP and cyclic AMP phosphodiesterases by certain nucleosides, nucleotides, and pharmacological phosphodiesterase inhibitors. Biochem Pharmacol. 1979 Apr 1;28(7):1107–1112. doi: 10.1016/0006-2952(79)90313-7. [DOI] [PubMed] [Google Scholar]
  10. Haesungcharern A., Chulavatnatol M. Stimulation of human spermatozoal motility by caffeine. Fertil Steril. 1973 Sep;24(9):662–665. doi: 10.1016/s0015-0282(16)39909-5. [DOI] [PubMed] [Google Scholar]
  11. Hartmann R., Steiner R., Hofmann N., Kaufmann R. Human sperm motility--enhancement and inhibition measured by laser Doppler spectroscopy. Andrologia. 1983 Mar-Apr;15(2):120–134. [PubMed] [Google Scholar]
  12. Helfman D. M., Kuo J. F. Differential effects of various phosphodiesterase inhibitors, pyrimidine and purine compounds, and inorganic phosphates on cyclic CMP, cyclic AMP and cyclic GMP phosphodiesterases. Biochem Pharmacol. 1982 Jan 1;31(1):43–47. doi: 10.1016/0006-2952(82)90233-7. [DOI] [PubMed] [Google Scholar]
  13. Hicks J. J., Martínez-Manautou J., Pedron N., Rosado A. Metabolic changes in human spermatozoa related to capacitation. Fertil Steril. 1972 Mar;23(3):172–179. [PubMed] [Google Scholar]
  14. Homonnai Z. T., Paz G., Sofer A., Kraicer P. F., Harell A. Effect of caffeine on the motility, viability, oxygen consumption and glycolytic rate of ejaculated human normokinetic and hypokinetic spermatozoa. Int J Fertil. 1976;21(3):162–170. [PubMed] [Google Scholar]
  15. Hong C. Y., Chaput de Saintonge D. M., Turner P. A simple method to measure drug effects on human sperm motility. Br J Clin Pharmacol. 1981 Apr;11(4):385–387. doi: 10.1111/j.1365-2125.1981.tb01137.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hoskins D. D., Hall M. L., Munsterman D. Induction of motility in immature bovine spermatozoa by cyclic AMP phosphodiesterase inhibitors and seminal plasma. Biol Reprod. 1975 Sep;13(2):168–176. doi: 10.1095/biolreprod13.2.168. [DOI] [PubMed] [Google Scholar]
  17. Johnston A., Aldhous M. E., Hedges A., Weerasuriya K., Freedman A., Turner P. The pharmacokinetics of lysine theophylline, a new soluble theophylline, in human volunteers. Postgrad Med J. 1983 Feb;59(688):86–87. doi: 10.1136/pgmj.59.688.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Levin R. M., Shofer J., Greenberg S. H. A quantitative method for determining the effects of drugs on spermatozoal motility. Fertil Steril. 1980 Jun;33(6):631–635. doi: 10.1016/s0015-0282(16)44777-1. [DOI] [PubMed] [Google Scholar]
  19. Makler A., Makler E., Itzkovitz J., Brandes J. M. Factors affecting sperm motility. IV. Incubation of human semen with caffeine, kallikrein, and other metabolically active compounds. Fertil Steril. 1980 Jun;33(6):624–630. [PubMed] [Google Scholar]
  20. McGrady A. V., Nelson L., Ireland M. Ionic effects on the motility of bull and chimpanzee spermatozoa. J Reprod Fertil. 1974 Sep;40(1):71–76. doi: 10.1530/jrf.0.0400071. [DOI] [PubMed] [Google Scholar]
  21. Morris M. B., Weinstein L. Caffeine and the fetus: is trouble brewing? Am J Obstet Gynecol. 1981 Jul 15;140(6):607–610. doi: 10.1016/0002-9378(81)90191-5. [DOI] [PubMed] [Google Scholar]
  22. Morton B. E., Sagadraca R., Fraser C. Sperm motility within the mammalian epididymis: species variation and correlation with free calcium levels in epididymal plasma. Fertil Steril. 1978 Jun;29(6):695–698. doi: 10.1016/s0015-0282(16)43348-0. [DOI] [PubMed] [Google Scholar]
  23. NISHIMURA H., NAKAI K. Congenital malformations in offspring of mice treated with caffeine. Proc Soc Exp Biol Med. 1960 May;104:140–142. doi: 10.3181/00379727-104-25757. [DOI] [PubMed] [Google Scholar]
  24. Peterson R. N., Seyler D., Bundman D., Freund M. The effect of theophylline and dibutyryl cyclic AMP on the uptake of radioactive calcium and phosphate ions by boar and human spermatozoa. J Reprod Fertil. 1979 Mar;55(2):385–390. doi: 10.1530/jrf.0.0550385. [DOI] [PubMed] [Google Scholar]
  25. Schoenfeld C., Amelar R. D., Dubin L. Stimulation of ejaculated human spermatozoa by caffeine. A preliminary report. Fertil Steril. 1973 Oct;24(10):772–775. doi: 10.1016/s0015-0282(16)39972-1. [DOI] [PubMed] [Google Scholar]
  26. Tash J. S., Means A. R. Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility. Biol Reprod. 1983 Feb;28(1):75–104. doi: 10.1095/biolreprod28.1.75. [DOI] [PubMed] [Google Scholar]

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