Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1985;19(Suppl 2):97S–105S. doi: 10.1111/j.1365-2125.1985.tb02749.x

Investigation of drug absorption from the gastrointestinal tract of man

I. Metoprolol in the stomach, duodenum and jejunum

G Jobin, A Cortot, J Godbillon, M Duval, J P Schoeller, J Hirtz, J J Bernier
PMCID: PMC1463760  PMID: 4005135

Abstract

1 Gastrointestinal (GI) absorption of the β-adrenoceptor blocker metoprolol was investigated in five healthy subjects by means of an intubation method, employing a triple-lumen tube introduced into the intestine, and a twin-lumen tube in the stomach. Metoprolol was introduced into the stomach with a homogenized meal containing a non-absorbable marker, [14C]-PEG 4000, and another marker, PEG 4000, was perfused continuously into the duodenum just below the pylorus. Samples of GI contents were collected at regular intervals over 4 h in the stomach and at two different levels in the upper small intestine.

2 Metoprolol was not absorbed from the stomach. Approximately 60% of the amount of drug emptied from the stomach was absorbed from the duodenum; about 50% of that leaving the duodenum was absorbed from the first part of the jejunum. The delivery process was the rate-limiting factor of metoprolol absorption in these segments of the gut.

3 Plasma concentrations reflected drug loss from the lumen and were higher in subjects exhibiting faster gastric emptying and higher absorption rates in the duodenum and jejunum.

4 The intubation technique appeared to be a suitable method for investigating drug absorption from the GI tract in man.

Keywords: drug absorption, metoprolol, stomach, duodenum, jejunum

Full text

PDF
99S

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Go V. L., Hofmann A. F., Summerskill W. H. Simultaneous measurements of total pancreatic, biliary, and gastric outputs in man using a perfusion technique. Gastroenterology. 1970 Mar;58(3):321–328. [PubMed] [Google Scholar]
  2. Hunt J. N., Stubbs D. F. The volume and energy content of meals as determinants of gastric emptying. J Physiol. 1975 Feb;245(1):209–225. doi: 10.1113/jphysiol.1975.sp010841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Jobin G., Cortot A., Danquechin-Dorval E., Godbillon J., Schoeller J. P., Bernier J. J., Hirtz J. Investigation of drug absorption from the gastrointestinal tract of man. V. Effect of the beta-adrenoceptor antagonist, metoprolol, on postprandial gastric function. Br J Clin Pharmacol. 1985;19 (Suppl 2):127S–135S. doi: 10.1111/j.1365-2125.1985.tb02753.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Longstreth G. F., Malagelada J. R., Go V. L. The gastric response to a transpyloric duodenal tube. Gut. 1975 Oct;16(10):777–780. doi: 10.1136/gut.16.10.777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. MacGregor I., Parent J., Meyer J. H. Gastric emptying of liquid meals and pancreatic and biliary secretion after subtotal gastrectomy or truncal vagotomy and pyloroplasty in man. Gastroenterology. 1977 Feb;72(2):195–205. [PubMed] [Google Scholar]
  6. Malagelada J. R., Go V. L., Summerskill W. H. Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals. Dig Dis Sci. 1979 Feb;24(2):101–110. doi: 10.1007/BF01324736. [DOI] [PubMed] [Google Scholar]
  7. Malagelada J. R., Longstreth G. F., Summerskill W. H., Go V. L. Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterology. 1976 Feb;70(2):203–210. [PubMed] [Google Scholar]
  8. Meeroff J. C., Go V. L., Phillips S. F. Control of gastric emptying by osmolality of duodenal contents in man. Gastroenterology. 1975 May;68(5 Pt 1):1144–1151. [PubMed] [Google Scholar]
  9. Rees W. D., Go V. L., Malagelada J. R. Simultaneous measurement of antroduodenal motility, gastric emptying, and duodenogastric reflux in man. Gut. 1979 Nov;20(11):963–970. doi: 10.1136/gut.20.11.963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sioufi A., Leroux F., Sandrenan N. Gas chromatographic determination of metoprolol in human plasma. J Chromatogr. 1983 Jan 14;272(1):103–110. doi: 10.1016/s0378-4347(00)86107-1. [DOI] [PubMed] [Google Scholar]
  11. Wingate D. L., Sandberg R. J., Phillips S. F. A comparison of stable and 14 C-labelled polyethylene glycol as volume indicators in the human jejunum. Gut. 1972 Oct;13(10):812–815. doi: 10.1136/gut.13.10.812. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES