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. 1996 Dec;104(Suppl 6):1159–1163. doi: 10.1289/ehp.961041159

Phenylguanine found in urine after benzene exposure.

K H Norpoth 1, G Müller 1, C Schell 1, E Jorg 1
PMCID: PMC1469737  PMID: 9118887

Abstract

Comparative investigations with synthetic N7-phenylguanine were carried out to clarify whether this compound is eliminated via the urine of rats as a benzene-derived nucleic acid adduct. As sensitive methods for detecting trace amounts of the compound, gas chromatography-mass spectroscopy, high performance liquid chromatography, and two immunoassays (enzyme-linked immunosorbent assay and fluoroimmunoassay) with appropriate monoclonal antibodies were used. The results indicate the excretion of several benzene-related guanine adducts slightly different from N7-phenylguanine that may possibly be hydroxylated. These adducts differ also from (O6-, N2- and C8-phenylguanine, respectively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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