Skip to main content
PMC home page
California Medicine logoLink to California Medicine
. 1971 Jun;114(6):17–25.

The role of phagocyte function in resistance to infection.

R I Lehrer
PMCID: PMC1501951  PMID: 4931050

Full text

PDF
22

Images in this article

23Figure 1.
on p.23
23Figure 2.
on p.23

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alper C. A., Abramson N., Johnston R. B., Jr, Jandl J. H., Rosen F. S. Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3). N Engl J Med. 1970 Feb 12;282(7):350–354. doi: 10.1056/nejm197002122820701. [DOI] [PubMed] [Google Scholar]
  2. Arakawa T., Wada Y., Hayashi T., Kakizaki R., Chida N., Chiba R., Konno T. Uracil-uric refractory anemia with peroxidase negative neutrophils. Tohoku J Exp Med. 1965 Oct 25;87(1):52–75. doi: 10.1620/tjem.87.52. [DOI] [PubMed] [Google Scholar]
  3. Axline S. G. Functional biochemistry of the macrophage. Semin Hematol. 1970 Apr;7(2):142–160. [PubMed] [Google Scholar]
  4. BOGGS D. R., ATHENS J. W., CARTWRIGHT G. E., WINTROBE M. M. THE EFFECT OF ADRENAL GLUCOCORTICOSTEROIDS UPON THE CELLULAR COMPOSITION OF INFLAMMATORY EXUDATES. Am J Pathol. 1964 May;44:763–773. [PMC free article] [PubMed] [Google Scholar]
  5. BOYDEN S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med. 1962 Mar 1;115:453–466. doi: 10.1084/jem.115.3.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BRIDGES R. A., BERENDES H., GOOD R. A. A fatal granulomatous disease of childhood; the clinical, pathological, and laboratory features of a new syndrome. AMA J Dis Child. 1959 Apr;97(4):387–408. [PubMed] [Google Scholar]
  7. Baehner R. L., Karnovsky M. L. Deficiency of reduced nicotinamide-adenine dinucleotide oxidase in chronic granulomatous disease. Science. 1968 Dec 13;162(3859):1277–1279. doi: 10.1126/science.162.3859.1277. [DOI] [PubMed] [Google Scholar]
  8. Baehner R. L., Nathan D. G. Quantitative nitroblue tetrazolium test in chronic granulomatous disease. N Engl J Med. 1968 May 2;278(18):971–976. doi: 10.1056/NEJM196805022781801. [DOI] [PubMed] [Google Scholar]
  9. Baggiolini M., Hirsch J. G., De Duve C. Resolution of granules from rabbit heterophil leukocytes into distinct populations by zonal sedimentation. J Cell Biol. 1969 Feb;40(2):529–541. doi: 10.1083/jcb.40.2.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bainton D. F., Farquhar M. G. Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes. I. Histochemical staining of bone marrow smears. J Cell Biol. 1968 Nov;39(2):286–298. doi: 10.1083/jcb.39.2.286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Bainton D. F., Farquhar M. G. Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes. II. Cytochemistry and electron microscopy of bone marrow cells. J Cell Biol. 1968 Nov;39(2):299–317. doi: 10.1083/jcb.39.2.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Bannatyne R. M., Skowron P. N., Weber J. L. Job's syndrome--a variant of chronic granulomatous disease. Report of a case. J Pediatr. 1969 Aug;75(2):236–242. doi: 10.1016/s0022-3476(69)80394-x. [DOI] [PubMed] [Google Scholar]
  13. Brayton R. G., Stokes P. E., Schwartz M. S., Louria D. B. Effect of alcohol and various diseases on leukocyte mobilization, phagocytosis and intracellular bacterial killing. N Engl J Med. 1970 Jan 15;282(3):123–128. doi: 10.1056/NEJM197001152820303. [DOI] [PubMed] [Google Scholar]
  14. CARSON M. J., CHADWICK D. L., BRUBAKER C. A., CLELAND R. S., LANDING B. H. THIRTEEN BOYS WITH PROGRESSIVE SEPTIC GRANULOMATOSIS. Pediatrics. 1965 Mar;35:405–412. [PubMed] [Google Scholar]
  15. CARTWRIGHT G. E., ATHENS J. W., WINTROBE M. M. THE KINETICS OF GRANULOPOIESIS IN NORMAL MAN. Blood. 1964 Dec;24:780–803. [PubMed] [Google Scholar]
  16. COHN Z. A., HIRSCH J. G. The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes. J Exp Med. 1960 Dec 1;112:983–1004. doi: 10.1084/jem.112.6.983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. COHN Z. A., MORSE S. I. Functional and metabolic properties of polymorphonuclear leucocytes. I. Observations on the requirements and consequences of particle ingestion. J Exp Med. 1960 May 1;111:667–687. doi: 10.1084/jem.111.5.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. COHN Z. A. The fate of bacteria within phagocytic cells. I. The degradation of isotopically labeled bacteria by polymorphonuclear leucocytes and macrophages. J Exp Med. 1963 Jan 1;117:27–42. doi: 10.1084/jem.117.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. DIZON Q. S., SOUTHAM C. M. ABNORMAL CELLULAR RESPONSE TO SKIN ABRASION IN CANCER PATIENTS. Cancer. 1963 Oct;16:1288–1292. doi: 10.1002/1097-0142(196310)16:10<1288::aid-cncr2820161009>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  20. Davis S. D., Schaller J., Wedgwood R. J. Job's Syndrome. Recurrent, "cold", staphylococcal abscesses. Lancet. 1966 May 7;1(7445):1013–1015. doi: 10.1016/s0140-6736(66)90119-x. [DOI] [PubMed] [Google Scholar]
  21. Davis W. C., Huber H., Douglas S. D., Fudenberg H. H. A defect in circulating mononuclear phagocytes in chronicgranulomatous disease of childhood. J Immunol. 1968 Nov;101(5):1093–1095. [PubMed] [Google Scholar]
  22. Douglas S. D. Analytic review: disorders of phagocyte function. Blood. 1970 Jun;35(6):851–866. [PubMed] [Google Scholar]
  23. Douglas S. D., Davis W. C., Fudenberg H. H. Granulocytopathies: pleomorphism of neutrophil dysfunction. Am J Med. 1969 Jun;46(6):901–909. doi: 10.1016/0002-9343(69)90091-6. [DOI] [PubMed] [Google Scholar]
  24. Good R. A., Quie P. G., Windhorst D. B., Page A. R., Rodey G. E., White J., Wolfson J. J., Holmes B. H. Fatal (chronic) granulomatous disease of childhood: a hereditary defect of leukocyte function. Semin Hematol. 1968 Jul;5(3):215–254. [PubMed] [Google Scholar]
  25. HARRIS H. Chemotaxis of granulocytes. J Pathol Bacteriol. 1953 Jul;66(1):135–146. doi: 10.1002/path.1700660117. [DOI] [PubMed] [Google Scholar]
  26. HIRSCH J. G. Cinemicrophotographic observations on granule lysis in polymorphonuclear leucocytes during phagocytosis. J Exp Med. 1962 Dec 1;116:827–834. doi: 10.1084/jem.116.6.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. HIRSCH J. G. Further studies on preparation and properties of phagocytin. J Exp Med. 1960 Mar 1;111:323–337. doi: 10.1084/jem.111.3.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. HIRSCH J. G., STRAUSS B. STUDIES ON HEAT-LABILE OPSONIN IN RABBIT SERUM. J Immunol. 1964 Jan;92:145–154. [PubMed] [Google Scholar]
  29. Hersh E. M., Wong V. G., Freireich E. J. Inhibition of the local inflammatory response in man by antimetabolites. Blood. 1966 Jan;27(1):38–48. [PubMed] [Google Scholar]
  30. Higashi O., Katsuyama N., Satodate R. A case with hematological abnormality characterized by the absence of peroxidase activity in blood polymorphonuclear leukocytes. Tohoku J Exp Med. 1965 Oct 25;87(1):77–89. doi: 10.1620/tjem.87.77. [DOI] [PubMed] [Google Scholar]
  31. Holmes B., Page A. R., Good R. A. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J Clin Invest. 1967 Sep;46(9):1422–1432. doi: 10.1172/JCI105634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Holmes B., Park B. H., Malawista S. E., Quie P. G., Nelson D. L., Good R. A. Chronic granulomatous disease in females. N Engl J Med. 1970 Jul 30;283(5):217–221. doi: 10.1056/NEJM197007302830501. [DOI] [PubMed] [Google Scholar]
  33. Huber H., Polley M. J., Linscott W. D., Fudenberg H. H., Müller-Eberhard H. J. Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G. Science. 1968 Dec 13;162(3859):1281–1283. doi: 10.1126/science.162.3859.1281. [DOI] [PubMed] [Google Scholar]
  34. Johnston R. B., Jr, Baehner R. L. Improvement of leukocyte bactericidal activity in chronic granulomatous disease. Blood. 1970 Mar;35(3):350–355. [PubMed] [Google Scholar]
  35. Johnston R. B., Jr, McMurry J. S. Chronic familial granulomatosis. Report of five cases and review of the literature. Am J Dis Child. 1967 Oct;114(4):370–378. doi: 10.1001/archpedi.1967.02090250068002. [DOI] [PubMed] [Google Scholar]
  36. KARNOVSKY M. L. Metabolic basis of phagocytic activity. Physiol Rev. 1962 Jan;42:143–168. doi: 10.1152/physrev.1962.42.1.143. [DOI] [PubMed] [Google Scholar]
  37. Kaplan E. L., Laxdal T., Quie P. G. Studies of polymorphonuclear leukocytes from patients with chronic granulomatous disease of childhood: bactericidal capacity for streptococci. Pediatrics. 1968 Mar;41(3):591–599. [PubMed] [Google Scholar]
  38. Karnovsky M. L. The metabolism of leukocytes. Semin Hematol. 1968 Apr;5(2):156–165. [PubMed] [Google Scholar]
  39. Keller H. U., Sorkin E. Chemotaxis of leucocytes. Experientia. 1968 Jul 15;24(7):641–652. doi: 10.1007/BF02138287. [DOI] [PubMed] [Google Scholar]
  40. Klebanoff S. J. Iodination of bacteria: a bactericidal mechanism. J Exp Med. 1967 Dec 1;126(6):1063–1078. doi: 10.1084/jem.126.6.1063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Klebanoff S. J. Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J Bacteriol. 1968 Jun;95(6):2131–2138. doi: 10.1128/jb.95.6.2131-2138.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Klebanoff S. J. Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes. Science. 1970 Sep 11;169(3950):1095–1097. doi: 10.1126/science.169.3950.1095. [DOI] [PubMed] [Google Scholar]
  43. Klebanoff S. J., White L. R. Iodination defect in the leukocytes of a patient with chronic granulomatous disease of childhood. N Engl J Med. 1969 Feb 27;280(9):460–466. doi: 10.1056/NEJM196902272800902. [DOI] [PubMed] [Google Scholar]
  44. Lay W. H., Nussenzweig V. Receptors for complement of leukocytes. J Exp Med. 1968 Nov 1;128(5):991–1009. doi: 10.1084/jem.128.5.991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Lehrer R. I. Antifungal effects of peroxidase systems. J Bacteriol. 1969 Aug;99(2):361–365. doi: 10.1128/jb.99.2.361-365.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Lehrer R. I., Cline M. J. Interaction of Candida albicans with human leukocytes and serum. J Bacteriol. 1969 Jun;98(3):996–1004. doi: 10.1128/jb.98.3.996-1004.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Lehrer R. I., Cline M. J. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest. 1969 Aug;48(8):1478–1488. doi: 10.1172/JCI106114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Lehrer R. I., Hanifin J., Cline M. J. Defective bactericidal activity in myeloperoxidase-deficient human neutrophils. Nature. 1969 Jul 5;223(5201):78–79. doi: 10.1038/223078a0. [DOI] [PubMed] [Google Scholar]
  49. LoBuglio A. F., Cotran R. S., Jandl J. H. Red cells coated with immunoglobulin G: binding and sphering by mononuclear cells in man. Science. 1967 Dec 22;158(3808):1582–1585. doi: 10.1126/science.158.3808.1582. [DOI] [PubMed] [Google Scholar]
  50. Mackaness G. B. The monocyte in cellular immunity. Semin Hematol. 1970 Apr;7(2):172–184. [PubMed] [Google Scholar]
  51. Mandell G. L., Hook E. W. Leukocyte function in chronic granulomatous disease of childhood. Studies on a seventeen year old boy. Am J Med. 1969 Sep;47(3):473–486. doi: 10.1016/0002-9343(69)90231-9. [DOI] [PubMed] [Google Scholar]
  52. McRipley R. J., Sbarra A. J. Role of the phagocyte in host-parasite interactions. XI. Relationship between stimulated oxidative metabolism and hydrogen peroxide formation, and intracellular killing. J Bacteriol. 1967 Nov;94(5):1417–1424. doi: 10.1128/jb.94.5.1417-1424.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. McRipley R. J., Sbarra A. J. Role of the phagocyte in host-parasite interactions. XII. Hydrogen peroxide-myeloperoxidase bactericidal system in the phagocyte. J Bacteriol. 1967 Nov;94(5):1425–1430. doi: 10.1128/jb.94.5.1425-1430.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Miller D. R., Kaplan H. G. Decreased nitroblue tetrazolium dye reduction in the phagocytes of patients receiving prednisone. Pediatrics. 1970 May;45(5):861–865. [PubMed] [Google Scholar]
  55. Miller M. E., Nilsson U. R. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5). N Engl J Med. 1970 Feb 12;282(7):354–358. doi: 10.1056/NEJM197002122820702. [DOI] [PubMed] [Google Scholar]
  56. PERILLIE P. E., FINCH S. C. QUANTITATIVE STUDIES OF THE LOCAL EXUDATIVE CELLULAR REACTION IN ACUTE LEUKEMIA. J Clin Invest. 1964 Mar;43:425–430. doi: 10.1172/JCI104927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. PERILLIE P. E., NOLAN J. P., FINCH S. C. Studies of the resistance to infection in diabetes mellitus: local exudative cellular response. J Lab Clin Med. 1962 Jun;59:1008–1015. [PubMed] [Google Scholar]
  58. PERRY S., CRADDOCK C. G., Jr, LAWRENCE J. S. Rates of appearance and disappearance of white blood cells in normal and in various disease states. J Lab Clin Med. 1958 Apr;51(4):501–515. [PubMed] [Google Scholar]
  59. Padgett G. A., Reiquam C. W., Gorham J. R., Henson J. B., O'Mary C. C. Comparative studies of the Chediak-Higashi syndrome. Am J Pathol. 1967 Oct;51(4):553–571. [PMC free article] [PubMed] [Google Scholar]
  60. Pearson H. A., Spencer R. P., Cornelius E. A. Functional asplenia in sickle-cell anemia. N Engl J Med. 1969 Oct 23;281(17):923–926. doi: 10.1056/NEJM196910232811703. [DOI] [PubMed] [Google Scholar]
  61. Perry S., Godwin H. A., Zimmerman T. S. Physiology of the granulocyte. 2. JAMA. 1968 Mar 18;203(12):1025–1032. doi: 10.1001/jama.203.12.1025. [DOI] [PubMed] [Google Scholar]
  62. Quie P. G., Kaplan E. L., Page A. R., Gruskay F. L., Malawista S. E. Defective polymorphonuclear-leukocyte function and chronic granulomatous disease in two female children. N Engl J Med. 1968 May 2;278(18):976–980. doi: 10.1056/NEJM196805022781802. [DOI] [PubMed] [Google Scholar]
  63. Quie P. G., Messner R. P., Williams R. C., Jr Phagocytosis in subacute bacterial endocarditis. Localization of the primary opsonic site to Fc fragment. J Exp Med. 1968 Oct 1;128(4):553–570. doi: 10.1084/jem.128.4.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Quie P. G., White J. G., Holmes B., Good R. A. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest. 1967 Apr;46(4):668–679. doi: 10.1172/JCI105568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. REBUCK J. W., CROWLEY J. H. A method of studying leukocytic functions in vivo. Ann N Y Acad Sci. 1955 Mar 24;59(5):757–805. doi: 10.1111/j.1749-6632.1955.tb45983.x. [DOI] [PubMed] [Google Scholar]
  66. Rodey G. E., Park B. H., Windhorst D. B., Good R. A. Defective bactericidal activity of monocytes in fatal granulomatous disease. Blood. 1969 Jun;33(6):813–820. [PubMed] [Google Scholar]
  67. SPITZNAGEL J. K., ZEYA H. I. BASIC PROTEINS AND LEUKOCYTE LYSOSOMES AS BIOCHEMICAL DETERMINANTS OF RESISTANCE TO INFECTION. Trans Assoc Am Physicians. 1964;77:126–134. [PubMed] [Google Scholar]
  68. Salmon S. E., Cline M. J., Schultz J., Lehrer R. I. Myeloperoxidase deficiency. Immunologic study of a genetic leukocyte defect. N Engl J Med. 1970 Jan 29;282(5):250–253. doi: 10.1056/NEJM197001292820505. [DOI] [PubMed] [Google Scholar]
  69. Shin H. S., Smith M. R., Wood W. B., Jr Heat labile opsonins to pneumococcus. II. Involvement of C3 and C5. J Exp Med. 1969 Dec 1;130(6):1229–1241. doi: 10.1084/jem.130.6.1229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Smith M. R., Wood W. B., Jr Heat labile opsonins to pneumococcus. I. Participation of complement. J Exp Med. 1969 Dec 1;130(6):1209–1227. doi: 10.1084/jem.130.6.1209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Southam C. M. The immunologic status of patients with nonlymphomatous cancer. Cancer Res. 1968 Jul;28(7):1433–1440. [PubMed] [Google Scholar]
  72. Undritz E. Die Alius-Grignaschi-Anomalie: Der erblich-konstitutionelle Peroxydasedefekt der Neutrophilen und Monozyten. Blut. 1966 Dec;14(3):129–136. doi: 10.1007/BF01631534. [DOI] [PubMed] [Google Scholar]
  73. Ward P. A. A plasmin-split fragment of C'3 as a new chemotactic factor. J Exp Med. 1967 Aug 1;126(2):189–206. doi: 10.1084/jem.126.2.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Ward P. A. Chemotoxis of mononuclear cells. J Exp Med. 1968 Nov 1;128(5):1201–1221. doi: 10.1084/jem.128.5.1201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Ward P. A., Cochrane C. G., Muller-Eberhard H. J. Further studies on the chemotactic factor of complement and its formation in vivo. Immunology. 1966 Aug;11(2):141–153. [PMC free article] [PubMed] [Google Scholar]
  76. Ward P. A., Newman L. J. A neutrophil chemotactic factor from human C'5. J Immunol. 1969 Jan;102(1):93–99. [PubMed] [Google Scholar]
  77. Ward P. A., Schlegel R. J. Impaired leucotactic responsiveness in a child with recurrent infections. Lancet. 1969 Aug 16;2(7616):344–347. doi: 10.1016/s0140-6736(69)92699-3. [DOI] [PubMed] [Google Scholar]
  78. Windhorst D. B., Page A. R., Holmes B., Quie P. G., Good R. A. The pattern of genetic transmission of the leukocyte defect in fatal granulomatous disease of childhood. J Clin Invest. 1968 May;47(5):1026–1034. doi: 10.1172/JCI105792. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Windhorst D. B., Zelickson A. S., Good R. A. Chediak-Higashi syndrome: hereditary gigantism of cytoplasmic organelles. Science. 1966 Jan 7;151(3706):81–83. doi: 10.1126/science.151.3706.81. [DOI] [PubMed] [Google Scholar]
  80. Winkelstein J. A., Drachman R. H. Deficiency of pneumococcal serum opsonizing activity in sickle-cell disease. N Engl J Med. 1968 Aug 29;279(9):459–466. doi: 10.1056/NEJM196808292790904. [DOI] [PubMed] [Google Scholar]
  81. Zeya H. I., Spitznagel J. K. Antimicrobial specificity of leukocyte lysosomal cationic proteins. Science. 1966 Nov 25;154(3752):1049–1051. doi: 10.1126/science.154.3752.1049. [DOI] [PubMed] [Google Scholar]
  82. Zeya H. I., Spitznagel J. K. Arginine-rich proteins of polymorphonuclear leukocyte lysosomes. Antimicrobial specificity and biochemical heterogeneity. J Exp Med. 1968 May 1;127(5):927–941. doi: 10.1084/jem.127.5.927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Zeya H. I., Spitznagel J. K. Cationic protein-bearing granules of polymorphonuclear leukocytes: separation from enzyme-rich granules. Science. 1969 Mar 7;163(3871):1069–1071. doi: 10.1126/science.163.3871.1069. [DOI] [PubMed] [Google Scholar]
  84. van Furth R., Cohn Z. A. The origin and kinetics of mononuclear phagocytes. J Exp Med. 1968 Sep 1;128(3):415–435. doi: 10.1084/jem.128.3.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. van Furth R. Origin and kinetics of monocytes and macrophages. Semin Hematol. 1970 Apr;7(2):125–141. [PubMed] [Google Scholar]

Articles from California Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES