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. 1993 Dec;101(Suppl 5):9–14. doi: 10.1289/ehp.93101s59

Cell cycle controls: potential targets for chemical carcinogens?

C A Afshari 1, J C Barrett 1
PMCID: PMC1519451  PMID: 8013430

Abstract

The progression of the cell cycle is controlled by the action of both positive and negative growth regulators. The key players in this activity include a family of cyclins and cyclin-dependent kinases, which are themselves regulated by other kinases and phosphatases. Maintenance of balanced cell cycle controls may be directly linked to genomic stability. Loss of the check-points involved in cell cycle control may result in unrepaired DNA damage during DNA synthesis or mitosis leading to genetic mutations and contributing to carcinogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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