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. 1972 Jun;11(2):255–264.

Autoimmune haemolytic anaemias. V. Studies on the resistance against complement haemolysis of the red cells of patients with chronic cold agglutinin disease

C P Engelfriet, A E G Kr Von Dem Borne, Do Beckers, E Reynierse, J J Van Loghem
PMCID: PMC1553619  PMID: 4114316

Abstract

Experiments are described the results of which sustain the hypothesis that resistance against complement haemolysis, which is a characteristic of the red cells of patients with chronic cold agglutinin disease, is due to the following mechanism: when red cells react with cold auto-agglutinins in vivo, they are either haemolysed immediately, or, due to an unknown factor, escape direct haemolysis. In the latter case β1E and β1A disappear from the cell membrane. To the sites where these proteins have been attached once, no new β1E or β1A molecules can be bound. Full complement activation thus becomes impossible.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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