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. 1977 Dec 10;2(6101):1513–1517. doi: 10.1136/bmj.2.6101.1513

Acute leukaemia after busulphan.

H Stott, W Fox, D J Girling, R J Stephens, D A Galton
PMCID: PMC1632782  PMID: 589308

Abstract

During a double-blind study of two years' cytotoxic chemotherapy with busulphan or cyclophosphamide in patients who had had resection of carcinoma of the bronchus the long-term effects of these two drugs were also studied. Four of the 243 patients treated with busulphan developed leukaemia compared with none of the 234 treated with cyclophosphamide and none of the 249 on placebo. None of these four patients received radiotherapy or other cytotoxic chemotherapy before leukaemia was diagnosed, and all four were among the 19 patients who developed pancytopenia while taking busulphan, five to eight years before leukaemia became clinically apparent. These findings suggest that busulphan is leukaemogenic, though its mode of action is uncertain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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