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. 1977 Dec 10;2(6101):1513–1517. doi: 10.1136/bmj.2.6101.1513

Acute leukaemia after busulphan.

H Stott, W Fox, D J Girling, R J Stephens, D A Galton
PMCID: PMC1632782  PMID: 589308

Abstract

During a double-blind study of two years' cytotoxic chemotherapy with busulphan or cyclophosphamide in patients who had had resection of carcinoma of the bronchus the long-term effects of these two drugs were also studied. Four of the 243 patients treated with busulphan developed leukaemia compared with none of the 234 treated with cyclophosphamide and none of the 249 on placebo. None of these four patients received radiotherapy or other cytotoxic chemotherapy before leukaemia was diagnosed, and all four were among the 19 patients who developed pancytopenia while taking busulphan, five to eight years before leukaemia became clinically apparent. These findings suggest that busulphan is leukaemogenic, though its mode of action is uncertain.

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Selected References

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  1. Allan W. S. Acute myeloid leukaemia after treatment with cytostatic agents. Lancet. 1970 Oct 10;2(7676):775–775. doi: 10.1016/s0140-6736(70)90250-3. [DOI] [PubMed] [Google Scholar]
  2. Andersen E., Videbaek A. Stem cell leukaemia in myelomatosis. Scand J Haematol. 1970;7(3):201–207. doi: 10.1111/j.1600-0609.1970.tb01888.x. [DOI] [PubMed] [Google Scholar]
  3. Bean R. H. Phenylbutazone and Leukaemia. Br Med J. 1960 Nov 26;2(5212):1552–1555. doi: 10.1136/bmj.2.5212.1552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CRONKITE E. P. Evidence for radiation and chemicals as leukemogenic agents. Arch Environ Health. 1961 Sep;3:297–303. doi: 10.1080/00039896.1961.10663025. [DOI] [PubMed] [Google Scholar]
  5. Catovsky D., Galton D. A. Myelomonocytic leukaemia supervening on chronic lymphocytic leukaemia. Lancet. 1971 Mar 6;1(7697):478–479. doi: 10.1016/s0140-6736(71)91091-9. [DOI] [PubMed] [Google Scholar]
  6. Chang J., Geary C. G. Therapy-linked leukemia. Lancet. 1977 Jan 8;1(8002):97–97. doi: 10.1016/s0140-6736(77)91113-8. [DOI] [PubMed] [Google Scholar]
  7. Cohen T., Creger W. P. Acute myeloid leukemia following seven years of aplastic anemia induced by chloramphenicol. Am J Med. 1967 Nov;43(5):762–770. doi: 10.1016/0002-9343(67)90118-0. [DOI] [PubMed] [Google Scholar]
  8. DEGOWIN R. L. BENZENE EXPOSURE AND APLASTIC ANEMIA FOLLOWED BY LEUKEMIA 15 YEARS LATER. JAMA. 1963 Sep 7;185:748–751. doi: 10.1001/jama.1963.03060100028011. [DOI] [PubMed] [Google Scholar]
  9. Dameshek W. Riddle: what do aplastic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and "hypoplastic" leukemia have in common? Blood. 1967 Aug;30(2):251–254. [PubMed] [Google Scholar]
  10. Davis H. L., Jr, Prout M. N., McKenna P. J., Cole D. R., Korbitz B. C. Acute leukemia complicating metastatic breast cancer. Cancer. 1973 Mar;31(3):543–546. doi: 10.1002/1097-0142(197303)31:3<543::aid-cncr2820310308>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  11. Delamore I. W., Geary C. G. Aplastic anaemia, acute myeloblastic leukaemia, and oxymetholone. Br Med J. 1971 Jun 26;2(5764):743–745. doi: 10.1136/bmj.2.5764.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. ELSON L. A., GALTON D. A., TILL M. The action of chlorambucil (CB. 1348) and busulphan (myleran) on the haemopoietic organs of the rat. Br J Haematol. 1958 Oct;4(4):355–374. doi: 10.1111/j.1365-2141.1958.tb06038.x. [DOI] [PubMed] [Google Scholar]
  13. Geary C. G. Therapy-linked leukaemia. Lancet. 1976 Oct 16;2(7990):862–862. doi: 10.1016/s0140-6736(76)91261-7. [DOI] [PubMed] [Google Scholar]
  14. Ishimaru T., Hoshino T., Ichimaru M., Okada H., Tomiyasu T. Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950--30 September 1966. Radiat Res. 1971 Jan;45(1):216–233. [PubMed] [Google Scholar]
  15. Karchmer R. K., Amare M., Larsen W. E., Mallouk A. G., Caldwell G. G. Alkylating agents as leukemogens in multiple myeloma. Cancer. 1974 Apr;33(4):1103–1107. doi: 10.1002/1097-0142(197404)33:4<1103::aid-cncr2820330432>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  16. Kaslow R. A., Wisch N., Glass J. L. Acute leukemia following cytotoxic chemotherapy. JAMA. 1972 Jan;219(1):75–76. [PubMed] [Google Scholar]
  17. Kyle R. A., Pierre R. V., Bayrd E. D. Multiple myeloma and acute myelomonocytic leukemia. N Engl J Med. 1970 Nov 19;283(21):1121–1125. doi: 10.1056/NEJM197011192832101. [DOI] [PubMed] [Google Scholar]
  18. Morley A., Trainor K., Blake J. A primary stem cell lesion in experimental chronic hypoplastic marrow failure. Blood. 1975 May;45(5):681–688. [PubMed] [Google Scholar]
  19. Roberts M. M. Acute leukaemia after immunosuppressive therapy. Lancet. 1976 Oct 9;2(7989):768–770. doi: 10.1016/s0140-6736(76)90601-2. [DOI] [PubMed] [Google Scholar]
  20. Smit C. G., Meyler L. Acute myeloid leukaemia after treatment with cytostatic agents. Lancet. 1970 Sep 26;2(7674):671–672. doi: 10.1016/s0140-6736(70)91448-0. [DOI] [PubMed] [Google Scholar]
  21. Stott H., Stephens R. J., Fox W., Roy D. C. 5-year follow-up of cytotoxic chemotherapy as an adjuvant to surgery in carcinoma of the bronchus. Br J Cancer. 1976 Aug;34(2):167–173. doi: 10.1038/bjc.1976.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tchernia G., Mielot F., Subtil E., Parmentier C. Acute myeloblastic leukemia after immunodepressive therapy for primary nonmalignant disease. Nouv Rev Fr Hematol Blood Cells. 1976;17(1-2):67–80. doi: 10.1007/978-3-642-66312-3_5. [DOI] [PubMed] [Google Scholar]
  23. VIGLIANI E. C., SAITA G. BENZENE AND LEUKEMIA. N Engl J Med. 1964 Oct 22;271:872–876. doi: 10.1056/NEJM196410222711703. [DOI] [PubMed] [Google Scholar]
  24. WOODLIFF H. J., DOUGAN L. ACUTE LEUKAEMIA ASSOCIATED WITH PHENYLBUTAZONE TREATMENT. Br Med J. 1964 Mar 21;1(5385):744–746. doi: 10.1136/bmj.1.5385.744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Weiden P. L., Lerner K. G., Gerdes A., Heywood J. D., Fefer A., Thomas E. D. Pancytopenia and leukemia in Hodgkin's disease: report of three cases. Blood. 1973 Oct;42(4):571–577. [PubMed] [Google Scholar]

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