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. 1972 Jan;44(1):10–16. doi: 10.1111/j.1476-5381.1972.tb07233.x

Resistance of noradrenaline in blood vessels to depletion by 6-hydroxydopamine or immunosympathectomy

B A Berkowitz, S Spector, J H Tarver
PMCID: PMC1665696  PMID: 4401306

Abstract

1. The degree of the decrease in the noradrenaline concentrations caused by 6-hydroxydopamine or immunosympathectomy was different in different areas of the cardiovascular system.

2. In rats or guinea-pigs 6-hydroxydopamine depleted the noradrenaline content of the heart by 90%, of the mesenteric vein by 80% and of the mesenteric artery and aorta by 30-60%. Immunosympathectomy elicited a 70% reduction in the cardiac noradrenaline but only a 50% reduction in the noradrenaline of the blood vessels of the rat.

3. The tyrosine hydroxylase activity of the heart, blood vessels, or adrenal glands was not significantly altered 2 weeks after 6-hydroxydopamine. Nor was the monoamine oxidase activity in heart or blood vessels changed.

4. The inconsistent ability of both 6-hydroxydopamine and immunosympathectomy to abolish experimental hypertension may be due to the partial persistence of noradrenaline and functional sympathetic nervous system activity in the blood vessels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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