Abstract
1. A new method for the estimation of 4-hydroxy-3-methoxyphenylethylamine (3-methoxytyramine) in brain tissue is described. This is based on the formation of a fluorescent derivative by oxidation with potassium ferricyanide in ammonium hydroxide solution.
2. The effects of some drugs on the concentration of 3-methoxytyramine in the brain are reported.
3. The significance of changes in the striatal concentration of 3-methoxytyramine is discussed.
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- ANDEN N. E., ROOS B. E., WERDINIUS B. On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method. Life Sci. 1963 Jul;(7):448–458. doi: 10.1016/0024-3205(63)90132-2. [DOI] [PubMed] [Google Scholar]
- CARLSSON A., LINDQVIST M. EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN. Acta Pharmacol Toxicol (Copenh) 1963;20:140–144. doi: 10.1111/j.1600-0773.1963.tb01730.x. [DOI] [PubMed] [Google Scholar]
- CARLSSON A., WALDECK B. A METHOD FOR THE FLUORIMETRIC DETERMINATION OF 3-METHOXYTYRAMINE IN TISSUES AND THE OCCURRENCE OF THIS AMINE IN BRAIN. Scand J Clin Lab Invest. 1964;16:133–138. doi: 10.1080/00365516409060495. [DOI] [PubMed] [Google Scholar]
- Crawford T. B., Yates C. M. A method for the estimation of the catecholamines and their metabolites in brain tissue. Br J Pharmacol. 1970 Jan;38(1):56–71. doi: 10.1111/j.1476-5381.1970.tb10336.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guldberg H. C., Yates C. M. Effects of chlorpromazine on the metabolism of catecholamines in dog brain. Br J Pharmacol. 1969 Jul;36(3):535–548. doi: 10.1111/j.1476-5381.1969.tb08009.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAGOPIAN M., DORFMAN R. I., GUT M. A method for the isolation and separation of catechol amines and their transformation products from biological media. Anal Biochem. 1961 Aug;2:387–390. doi: 10.1016/0003-2697(61)90013-6. [DOI] [PubMed] [Google Scholar]
- Jonas W., Scheel-Krüger J. Amphetamine induced stereotyped behaviour correlated with the accumulation of O-methylated dopamine. Arch Int Pharmacodyn Ther. 1969 Feb;177(2):379–389. [PubMed] [Google Scholar]
- LAVERTY R., SHARMAN D. F. THE ESTIMATION OF SMALL QUANTITIES OF 3,4-DIHYDROXYPHENYLETHYLAMINE IN TISSUES. Br J Pharmacol Chemother. 1965 Apr;24:538–548. doi: 10.1111/j.1476-5381.1965.tb01744.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Laverty R., Taylor K. M. The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique. Anal Biochem. 1968 Feb;22(2):269–279. doi: 10.1016/0003-2697(68)90316-3. [DOI] [PubMed] [Google Scholar]
- Lisch H. J., Aigner A., Hornykiewicz O. Dopamin-Stoffwechsel im Nucleus caudatus des Kaninchens nach partieller Hemmung der Gehirn-Monoaminoxydase mittels Nialamid. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;261(4):289–298. [PubMed] [Google Scholar]
- Tagliamonte A., Tagliamonte P., Gessa G. L. Reserpine-like action of chlorpromazine on rabbit basal ganglia. J Neurochem. 1970 Jun;17(6):733–738. doi: 10.1111/j.1471-4159.1970.tb03343.x. [DOI] [PubMed] [Google Scholar]