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. 1989 Aug;45(2):304–309.

Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304).

N Dahl 1, P Goonewardena 1, H Malmgren 1, K H Gustavson 1, G Holmgren 1, E Seemanova 1, G Annerén 1, A Flood 1, U Pettersson 1
PMCID: PMC1683358  PMID: 2569270

Abstract

A new polymorphic DNA marker U6.2, defining the locus DXS304, was recently isolated and mapped to the Xq27 region of the X chromosome. In the previous communication we describe a linkage study encompassing 16 fragile-X families and using U6.2 and five previously described polymorphic markers at Xq26-q28. One recombination event was observed between DXS304 and the fragile-X locus in 36 informative meioses. Combined with information from other reports, our results suggest the following order of the examined loci on Xq: cen-F9-DXS105-DXS98-FRAXA-DXS304-(DXS52-F8 -DXS15). The locus DXS304 is closely linked to FRAXA, giving a peak lod score of 5.86 at a corresponding recombination fraction of .00. On the basis of the present results, it is apparent that U6.2 is a useful probe for carrier and prenatal diagnosis in fragile-X families.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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