Abstract
The biological activities of prostaglandins E1, E2, E3 and F1α have been compared. Prostaglandins E1, E2, E3 were qualitatively similar; E1 and E2 were about equiactive, but E3 was less active on all preparations. Prostaglandin F1α was a less potent vasodilator than E1 on the cat gastrocnemius muscle blood flow and skin blood flow and a less potent depressor drug on rabbit blood pressure. On the rabbit isolated jejunum F1α was twice as active as E1 but on the guinea-pig isolated ileum E1 was about forty times more active than F1α. One qualitative difference between these prostaglandins was observed; on the rabbit fallopian tube in vivo prostaglandins of the E series decreased both the tone and the peristalsis of the tube whereas prostaglandin F1α increased tubal tone.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERGSTROM S., ELIASSON R., von EULER U., SJOVALL J. Some biological effects of two crystalline prostaglandin factors. Acta Physiol Scand. 1959 Mar 31;45:133–144. doi: 10.1111/j.1748-1716.1959.tb01685.x. [DOI] [PubMed] [Google Scholar]
- BERGSTROM S., SAMUELSSON B. Isolation of prostaglandin E1 from human seminal plasma. Prostaglandins and related factors. 11. J Biol Chem. 1962 Sep;237:3005–3006. [PubMed] [Google Scholar]
- Goldblatt M. W. Properties of human seminal plasma. J Physiol. 1935 May 13;84(2):208–218. doi: 10.1113/jphysiol.1935.sp003269. [DOI] [PMC free article] [PubMed] [Google Scholar]