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. 1971 Jun;8(6):957–962.

Immune responses in aged mice: changes of antibody-forming cell precursors in antigen-reactive cells with ageing

S Kishimoto, Y Yamamura
PMCID: PMC1713036  PMID: 4933320

Abstract

The depressed immune response to sheep erythrocytes in young syngeneic irradiated recipients, adoptively restored with splenic cells from old donor mice, was used as an index of the changes in the immunocompentent cells with ageing. The numbers of antibody-forming cell precursors in both spleen and bone marrow appeared to be diminished with ageing. Some reduction of antigen-reactive cells was also observed in old spleens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albright J. F., Makinodan T. Growth and senescence of antibody-forming cells. J Cell Physiol. 1966 Jun;67(3 Suppl):185+–185+. doi: 10.1002/jcp.1040670415. [DOI] [PubMed] [Google Scholar]
  2. Claman H. N., Chaperon E. A., Triplett R. F. Thymus-marrow cell combinations. Synergism in antibody production. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167–1171. doi: 10.3181/00379727-122-31353. [DOI] [PubMed] [Google Scholar]
  3. Hildemann W. H., Walford R. L. Autoimmunity in relation to aging as measured by agar plaque technique. Proc Soc Exp Biol Med. 1966 Nov;123(2):417–421. doi: 10.3181/00379727-123-31502. [DOI] [PubMed] [Google Scholar]
  4. JERNE N. K., NORDIN A. A. Plaque formation in agar by single antibody-producing cells. Science. 1963 Apr 26;140(3565):405–405. [PubMed] [Google Scholar]
  5. Kennedy J. C., Siminovitch L., Till J. E., McCulloch E. A. A transplantation assay for mouse cells responsive to antigenic stimulation by sheep erythrocytes. Proc Soc Exp Biol Med. 1965 Dec;120(3):868–873. doi: 10.3181/00379727-120-30678. [DOI] [PubMed] [Google Scholar]
  6. Kishimoto S., Tsuyuguchi I., Yamamura Y. Immune responses in aged mice. Clin Exp Immunol. 1969 Nov;5(5):525–530. [PMC free article] [PubMed] [Google Scholar]
  7. Linna T. J., Lidén S. Cell migration from the bone marrow to the spleen in young guinea pigs. Int Arch Allergy Appl Immunol. 1969;35(1):35–46. doi: 10.1159/000230157. [DOI] [PubMed] [Google Scholar]
  8. MAKINODAN T., PETERSON W. J. GROWTH AND SENESCENCE OF THE PRIMARY ANTIBODT-FORMING POTENTIAL OF THE SPLEEN. J Immunol. 1964 Dec;93:886–896. [PubMed] [Google Scholar]
  9. MAKINODAN T., PETERSON W. J. Relative antibody-forming capacity of spleen cells as a function of age. Proc Natl Acad Sci U S A. 1962 Feb;48:234–238. doi: 10.1073/pnas.48.2.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Metcalf D., Moulds R., Pike B. Influence of the spleen and thymus on immune responses in ageing mice. Clin Exp Immunol. 1967 Jan;2(1):109–120. [PMC free article] [PubMed] [Google Scholar]
  11. Miller J. F., Mitchell G. F. Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes. J Exp Med. 1968 Oct 1;128(4):801–820. doi: 10.1084/jem.128.4.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mitchell G. F., Miller J. F. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J Exp Med. 1968 Oct 1;128(4):821–837. doi: 10.1084/jem.128.4.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nossal G. J., Cunningham A., Mitchell G. F., Miller J. F. Cell to cell interaction in the immune response. 3. Chromosomal marker analysis of single antibody-forming cells in reconstituted, irradiated, or thymectomized mice. J Exp Med. 1968 Oct 1;128(4):839–853. doi: 10.1084/jem.128.4.839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Roitt I. M., Greaves M. F., Torrigiani G., Brostoff J., Playfair J. H. The cellular basis of immunological responses. A synthesis of some current views. Lancet. 1969 Aug 16;2(7616):367–371. doi: 10.1016/s0140-6736(69)92712-3. [DOI] [PubMed] [Google Scholar]
  15. Rowley M. J., Buchanan H., Mackay I. R. Reciprocal change with age in antibody to extrinsic and intrinsic antigens. Lancet. 1968 Jul 6;2(7558):24–26. doi: 10.1016/s0140-6736(68)92893-6. [DOI] [PubMed] [Google Scholar]
  16. Shearer G. M., Cudkowicz G., Priore R. L. Cellular differentiation of the immune system of mice. IV. Lack of class differentiation in thymic antigen-reactive cells. J Exp Med. 1969 Sep 1;130(3):467–480. doi: 10.1084/jem.130.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Talmage D. W., Hemmingsen H. Cell interaction in antibody synthesis. J Allergy. 1969 Jun;43(6):323–335. doi: 10.1016/0021-8707(69)90077-x. [DOI] [PubMed] [Google Scholar]

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