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. 1971 Jun;8(6):957–962.

Immune responses in aged mice: changes of antibody-forming cell precursors in antigen-reactive cells with ageing

S Kishimoto, Y Yamamura
PMCID: PMC1713036  PMID: 4933320

Abstract

The depressed immune response to sheep erythrocytes in young syngeneic irradiated recipients, adoptively restored with splenic cells from old donor mice, was used as an index of the changes in the immunocompentent cells with ageing. The numbers of antibody-forming cell precursors in both spleen and bone marrow appeared to be diminished with ageing. Some reduction of antigen-reactive cells was also observed in old spleens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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