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. 1971 Sep;9(3):329–337.

Antibodies to skeletal muscle demonstrated by immunofluorescence in experimental autoallergic myositis

R L Dawkins, A Eghtedari, E J Holborow
PMCID: PMC1713072  PMID: 4936871

Abstract

Immunization of inbred guinea-pigs with xenogeneic skeletal muscle can induce the development of a focal segmental myositis associated with the presence of a serum antibody which binds to the cross-striations of isogeneic or xenogeneic skeletal muscle as shown by indirect immunofluorescence. This antibody also produces striational staining of chick myoid cells. The association of striation-binding antibody with some forms of human and animal myositis is emphasized. It is concluded, however, that myositis is unlikely to be directly due to humoral antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Feltkamp T. E., Feltkamp-Vroom T. M. Antibodies against the various types of skeletal muscle fibres. Immunology. 1965 Sep;9(3):275–279. [PMC free article] [PubMed] [Google Scholar]
  2. Fessel W. J., Raas M. C. Autoimmunity in the pathogenesis of muscle disease. Neurology. 1968 Nov;18(11):1137–1139. doi: 10.1212/wnl.18.11.1137. [DOI] [PubMed] [Google Scholar]
  3. Goldstein G., Whittingham S. Histological and serological features of experimental autoimmune thymitis in guinea-pigs. Clin Exp Immunol. 1967 May;2(3):257–268. [PMC free article] [PubMed] [Google Scholar]
  4. Kakulas B. A. Destruction of differentiated muscle cultures by sensitised lymphoid cells. J Pathol Bacteriol. 1966 Apr;91(2):495–503. doi: 10.1002/path.1700910225. [DOI] [PubMed] [Google Scholar]
  5. Kalden J. R., Williamson W. G., Johnston R. J., Irvine W. J. Studies on experimental autoimmune thymitis in guinea-pigs. Clin Exp Immunol. 1969 Oct;5(4):319–340. [PMC free article] [PubMed] [Google Scholar]
  6. Oosterhuis H. J., Bethlem J., Feltkamp T. E. Muscle pathology, thymoma, and immunological abnormalities in patients with myasthenia gravis. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):460–463. doi: 10.1136/jnnp.31.5.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pepe F. A. Analysis of antibody staining patterns obtained with striated myofibrils in fluorescence microscopy and electron microscopy. Int Rev Cytol. 1968;24:193–231. doi: 10.1016/s0074-7696(08)61400-x. [DOI] [PubMed] [Google Scholar]
  8. RUSSELL D. S. Histological changes in the striped muscles in myasthenia gravis. J Pathol Bacteriol. 1953 Apr;65(2):279–289. doi: 10.1002/path.1700650202. [DOI] [PubMed] [Google Scholar]
  9. Stern G. M., Rose A. L., Jacobs K. Circulating antibodies in polymyositis. J Neurol Sci. 1967 Jul-Aug;5(1):181–183. doi: 10.1016/0022-510x(67)90015-9. [DOI] [PubMed] [Google Scholar]
  10. Stewart H. L., Snell K. C. Thymomas and thymic hyperplasia in Praomys (Mastomys) natalensis. Concomitant myositis, myocarditis, and sialodacryoadenitis. J Natl Cancer Inst. 1968 Jun;40(6):1135–1159. [PubMed] [Google Scholar]
  11. Strauss A. J., Kemp P. G., Jr Serum autoantibodies in myasthenia gravis and thymoma: selective affinity for I-bands of striated muscle as a guide to identification of antigen(s). J Immunol. 1967 Nov;99(5):945–953. [PubMed] [Google Scholar]
  12. Strauss A. J., Snell K. C., Duntley B. J., Soban E. J., Stewart H. L. Spontaneous thymoma, polymyositis, and serum-autoantibodies to striated muscle in the rodent, subgenus Praomys (Mastomys) natalensis. Similarities to thymoma with myasthenia gravis in man. Lancet. 1968 May 25;1(7552):1126–1129. doi: 10.1016/s0140-6736(68)90189-x. [DOI] [PubMed] [Google Scholar]
  13. Vetters J. M., Simpson J. A., Folkarde A. Experimental myasthenia gravis. Lancet. 1969 Jul 5;2(7610):28–31. doi: 10.1016/s0140-6736(69)92601-4. [DOI] [PubMed] [Google Scholar]

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