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. 2002 Oct;57(Suppl 2):ii15–ii23.

MANAGEMENT OF AN ACUTE EXACERBATION OF COPD: ARE WE IGNORING THE EVIDENCE?

M Johnson, R Stevenson
PMCID: PMC1766002  PMID: 12364706

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Selected References

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  1. Ambrosino N., Foglio K., Rubini F., Clini E., Nava S., Vitacca M. Non-invasive mechanical ventilation in acute respiratory failure due to chronic obstructive pulmonary disease: correlates for success. Thorax. 1995 Jul;50(7):755–757. doi: 10.1136/thx.50.7.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Angus R. M., Ahmed A. A., Fenwick L. J., Peacock A. J. Comparison of the acute effects on gas exchange of nasal ventilation and doxapram in exacerbations of chronic obstructive pulmonary disease. Thorax. 1996 Oct;51(10):1048–1050. doi: 10.1136/thx.51.10.1048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Anthonisen N. R., Manfreda J., Warren C. P., Hershfield E. S., Harding G. K., Nelson N. A. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987 Feb;106(2):196–204. doi: 10.7326/0003-4819-106-2-196. [DOI] [PubMed] [Google Scholar]
  4. Aylward M. A between-patient, double-blind comparison of S-carboxymethylcysteine and bromhexine in chronic obstructive bronchitis. Curr Med Res Opin. 1973;1(4):219–227. doi: 10.1185/03007997309111671. [DOI] [PubMed] [Google Scholar]
  5. Bedon G. A., Block A. J., Ball W. C., Jr The "28 percent" Venturi mask in obstructive airway disease. Arch Intern Med. 1970 Jan;125(1):106–113. [PubMed] [Google Scholar]
  6. Bhowmik A., Seemungal T. A., Sapsford R. J., Wedzicha J. A. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax. 2000 Feb;55(2):114–120. doi: 10.1136/thorax.55.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bone R. C., Pierce A. K., Johnson R. L., Jr Controlled oxygen administration in acute respiratory failure in chronic obstructive pulmonary disease: a reappraisal. Am J Med. 1978 Dec;65(6):896–902. doi: 10.1016/0002-9343(78)90740-4. [DOI] [PubMed] [Google Scholar]
  8. Bott J., Carroll M. P., Conway J. H., Keilty S. E., Ward E. M., Brown A. M., Paul E. A., Elliott M. W., Godfrey R. C., Wedzicha J. A. Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease. Lancet. 1993 Jun 19;341(8860):1555–1557. doi: 10.1016/0140-6736(93)90696-e. [DOI] [PubMed] [Google Scholar]
  9. Bowen J. B., Thrall R. S., ZuWallack R. L., Votto J. J. Long-term benefits of short-stay inpatient pulmonary rehabilitation in severe chronic obstructive pulmonary disease. Monaldi Arch Chest Dis. 1999 Apr;54(2):189–192. [PubMed] [Google Scholar]
  10. Breen D., Churches T., Hawker F., Torzillo P. J. Acute respiratory failure secondary to chronic obstructive pulmonary disease treated in the intensive care unit: a long term follow up study. Thorax. 2002 Jan;57(1):29–33. doi: 10.1136/thorax.57.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Brochard L., Mancebo J., Wysocki M., Lofaso F., Conti G., Rauss A., Simonneau G., Benito S., Gasparetto A., Lemaire F. Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 1995 Sep 28;333(13):817–822. doi: 10.1056/NEJM199509283331301. [DOI] [PubMed] [Google Scholar]
  12. Burge P. S., Calverley P. M., Jones P. W., Spencer S., Anderson J. A., Maslen T. K. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ. 2000 May 13;320(7245):1297–1303. doi: 10.1136/bmj.320.7245.1297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Casaburi R., Mahler D. A., Jones P. W., Wanner A., San Pedro G., ZuWallack R. L., Menjoge S. S., Serby C. W., Witek T., Jr A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J. 2002 Feb;19(2):217–224. doi: 10.1183/09031936.02.00269802. [DOI] [PubMed] [Google Scholar]
  14. Confalonieri M., Potena A., Carbone G., Porta R. D., Tolley E. A., Umberto Meduri G. Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation. Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1585–1591. doi: 10.1164/ajrccm.160.5.9903015. [DOI] [PubMed] [Google Scholar]
  15. Connors A. F., Jr, Dawson N. V., Thomas C., Harrell F. E., Jr, Desbiens N., Fulkerson W. J., Kussin P., Bellamy P., Goldman L., Knaus W. A. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments) Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):959–967. doi: 10.1164/ajrccm.154.4.8887592. [DOI] [PubMed] [Google Scholar]
  16. Costello R., Deegan P., Fitzpatrick M., McNicholas W. T. Reversible hypercapnia in chronic obstructive pulmonary disease: a distinct pattern of respiratory failure with a favorable prognosis. Am J Med. 1997 Mar;102(3):239–244. doi: 10.1016/S0002-9343(97)00017-X. [DOI] [PubMed] [Google Scholar]
  17. Cotton M. M., Bucknall C. E., Dagg K. D., Johnson M. K., MacGregor G., Stewart C., Stevenson R. D. Early discharge for patients with exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Thorax. 2000 Nov;55(11):902–906. doi: 10.1136/thorax.55.11.902. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Davies L., Angus R. M., Calverley P. M. Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial. Lancet. 1999 Aug 7;354(9177):456–460. doi: 10.1016/s0140-6736(98)11326-0. [DOI] [PubMed] [Google Scholar]
  19. Davies L., Wilkinson M., Bonner S., Calverley P. M., Angus R. M. "Hospital at home" versus hospital care in patients with exacerbations of chronic obstructive pulmonary disease: prospective randomised controlled trial. BMJ. 2000 Nov 18;321(7271):1265–1268. doi: 10.1136/bmj.321.7271.1265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Dunn W. F., Nelson S. B., Hubmayr R. D. Oxygen-induced hypercarbia in obstructive pulmonary disease. Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):526–530. doi: 10.1164/ajrccm/144.3_Pt_1.526. [DOI] [PubMed] [Google Scholar]
  21. Eldridge F., Gherman C. Studies of oxygen administration in respiratory failure. Ann Intern Med. 1968 Mar;68(3):569–578. doi: 10.7326/0003-4819-68-3-569. [DOI] [PubMed] [Google Scholar]
  22. Emerman C. L., Cydulka R. K. Evaluation of high-yield criteria for chest radiography in acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med. 1993 Apr;22(4):680–684. doi: 10.1016/s0196-0644(05)81847-5. [DOI] [PubMed] [Google Scholar]
  23. Fine M. J., Smith M. A., Carson C. A., Meffe F., Sankey S. S., Weissfeld L. A., Detsky A. S., Kapoor W. N. Efficacy of pneumococcal vaccination in adults. A meta-analysis of randomized controlled trials. Arch Intern Med. 1994 Dec 12;154(23):2666–2677. doi: 10.1001/archinte.1994.00420230051007. [DOI] [PubMed] [Google Scholar]
  24. Fletcher C., Peto R. The natural history of chronic airflow obstruction. Br Med J. 1977 Jun 25;1(6077):1645–1648. doi: 10.1136/bmj.1.6077.1645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Foglio K., Bianchi L., Bruletti G., Battista L., Pagani M., Ambrosino N. Long-term effectiveness of pulmonary rehabilitation in patients with chronic airway obstruction. Eur Respir J. 1999 Jan;13(1):125–132. doi: 10.1183/09031936.99.13112599. [DOI] [PubMed] [Google Scholar]
  26. Friedman M., Serby C. W., Menjoge S. S., Wilson J. D., Hilleman D. E., Witek T. J., Jr Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD. Chest. 1999 Mar;115(3):635–641. doi: 10.1378/chest.115.3.635. [DOI] [PubMed] [Google Scholar]
  27. Gibson P. G., Wlodarczyk J. H., Wilson A. J., Sprogis A. Severe exacerbation of chronic obstructive airways disease: health resource use in general practice and hospital. J Qual Clin Pract. 1998 Jun;18(2):125–133. [PubMed] [Google Scholar]
  28. Girault C., Daudenthun I., Chevron V., Tamion F., Leroy J., Bonmarchand G. Noninvasive ventilation as a systematic extubation and weaning technique in acute-on-chronic respiratory failure: a prospective, randomized controlled study. Am J Respir Crit Care Med. 1999 Jul;160(1):86–92. doi: 10.1164/ajrccm.160.1.9802120. [DOI] [PubMed] [Google Scholar]
  29. Gompertz S., Bayley D. L., Hill S. L., Stockley R. A. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. Thorax. 2001 Jan;56(1):36–41. doi: 10.1136/thorax.56.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Gravil J. H., Al-Rawas O. A., Cotton M. M., Flanigan U., Irwin A., Stevenson R. D. Home treatment of exacerbations of chronic obstructive pulmonary disease by an acute respiratory assessment service. Lancet. 1998 Jun 20;351(9119):1853–1855. doi: 10.1016/s0140-6736(97)11048-0. [DOI] [PubMed] [Google Scholar]
  31. Griffiths T. L., Burr M. L., Campbell I. A., Lewis-Jenkins V., Mullins J., Shiels K., Turner-Lawlor P. J., Payne N., Newcombe R. G., Ionescu A. A. Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial. Lancet. 2000 Jan 29;355(9201):362–368. doi: 10.1016/s0140-6736(99)07042-7. [DOI] [PubMed] [Google Scholar]
  32. Gross P. A., Hermogenes A. W., Sacks H. S., Lau J., Levandowski R. A. The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature. Ann Intern Med. 1995 Oct 1;123(7):518–527. doi: 10.7326/0003-4819-123-7-199510010-00008. [DOI] [PubMed] [Google Scholar]
  33. Gust R., Gottschalk A., Schmidt H., Böttiger B. W., Böhrer H., Martin E. Effects of continuous (CPAP) and bi-level positive airway pressure (BiPAP) on extravascular lung water after extubation of the trachea in patients following coronary artery bypass grafting. Intensive Care Med. 1996 Dec;22(12):1345–1350. doi: 10.1007/BF01709549. [DOI] [PubMed] [Google Scholar]
  34. Güell R., Casan P., Belda J., Sangenis M., Morante F., Guyatt G. H., Sanchis J. Long-term effects of outpatient rehabilitation of COPD: A randomized trial. Chest. 2000 Apr;117(4):976–983. doi: 10.1378/chest.117.4.976. [DOI] [PubMed] [Google Scholar]
  35. Holleman D. R., Jr, Simel D. L. Does the clinical examination predict airflow limitation? JAMA. 1995 Jan 25;273(4):313–319. [PubMed] [Google Scholar]
  36. Holleman D. R., Jr, Simel D. L., Goldberg J. S. Diagnosis of obstructive airways disease from the clinical examination. J Gen Intern Med. 1993 Feb;8(2):63–68. doi: 10.1007/BF02599985. [DOI] [PubMed] [Google Scholar]
  37. Jeffrey A. A., Warren P. M., Flenley D. C. Acute hypercapnic respiratory failure in patients with chronic obstructive lung disease: risk factors and use of guidelines for management. Thorax. 1992 Jan;47(1):34–40. doi: 10.1136/thx.47.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Jiang J. S., Kao S. J., Wang S. N. Effect of early application of biphasic positive airway pressure on the outcome of extubation in ventilator weaning. Respirology. 1999 Jun;4(2):161–165. doi: 10.1046/j.1440-1843.1999.00168.x. [DOI] [PubMed] [Google Scholar]
  39. Kanner R. E., Anthonisen N. R., Connett J. E., Lung Health Study Research Group Lower respiratory illnesses promote FEV(1) decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: results from the lung health study. Am J Respir Crit Care Med. 2001 Aug 1;164(3):358–364. doi: 10.1164/ajrccm.164.3.2010017. [DOI] [PubMed] [Google Scholar]
  40. Karpel J. P., Pesin J., Greenberg D., Gentry E. A comparison of the effects of ipratropium bromide and metaproterenol sulfate in acute exacerbations of COPD. Chest. 1990 Oct;98(4):835–839. doi: 10.1378/chest.98.4.835. [DOI] [PubMed] [Google Scholar]
  41. Koivula I., Stén M., Leinonen M., Mäkelä P. H. Clinical efficacy of pneumococcal vaccine in the elderly: a randomized, single-blind population-based trial. Am J Med. 1997 Oct;103(4):281–290. doi: 10.1016/s0002-9343(97)00149-6. [DOI] [PubMed] [Google Scholar]
  42. Kramer N., Meyer T. J., Meharg J., Cece R. D., Hill N. S. Randomized, prospective trial of noninvasive positive pressure ventilation in acute respiratory failure. Am J Respir Crit Care Med. 1995 Jun;151(6):1799–1806. doi: 10.1164/ajrccm.151.6.7767523. [DOI] [PubMed] [Google Scholar]
  43. Kuschner W. G. What exactly is flock worker's lung? Chest. 2000 Jan;117(1):10–13. doi: 10.1378/chest.117.1.10. [DOI] [PubMed] [Google Scholar]
  44. Langlands J. H. Double-blind clinical trial of bromhexine as a mucolytic drug in chronic bronchitis. Lancet. 1970 Feb 28;1(7644):448–450. doi: 10.1016/s0140-6736(70)90835-4. [DOI] [PubMed] [Google Scholar]
  45. Mahler D. A., Donohue J. F., Barbee R. A., Goldman M. D., Gross N. J., Wisniewski M. E., Yancey S. W., Zakes B. A., Rickard K. A., Anderson W. H. Efficacy of salmeterol xinafoate in the treatment of COPD. Chest. 1999 Apr;115(4):957–965. doi: 10.1378/chest.115.4.957. [DOI] [PubMed] [Google Scholar]
  46. Martin T. J., Hovis J. D., Costantino J. P., Bierman M. I., Donahoe M. P., Rogers R. M., Kreit J. W., Sciurba F. C., Stiller R. A., Sanders M. H. A randomized, prospective evaluation of noninvasive ventilation for acute respiratory failure. Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):807–813. doi: 10.1164/ajrccm.161.3.9808143. [DOI] [PubMed] [Google Scholar]
  47. McEvoy C. E., Niewoehner D. E. Adverse effects of corticosteroid therapy for COPD. A critical review. Chest. 1997 Mar;111(3):732–743. doi: 10.1378/chest.111.3.732. [DOI] [PubMed] [Google Scholar]
  48. McEvoy C. E., Niewoehner D. E. Corticosteroids in chronic obstructive pulmonary disease. Clinical benefits and risks. Clin Chest Med. 2000 Dec;21(4):739–752. doi: 10.1016/s0272-5231(05)70181-7. [DOI] [PubMed] [Google Scholar]
  49. Miravitlles M., Espinosa C., Fernández-Laso E., Martos J. A., Maldonado J. A., Gallego M. Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Study Group of Bacterial Infection in COPD. Chest. 1999 Jul;116(1):40–46. doi: 10.1378/chest.116.1.40. [DOI] [PubMed] [Google Scholar]
  50. Moayyedi P., Congleton J., Page R. L., Pearson S. B., Muers M. F. Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease. Thorax. 1995 Aug;50(8):834–837. doi: 10.1136/thx.50.8.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Monsó E., Ruiz J., Rosell A., Manterola J., Fiz J., Morera J., Ausina V. Bacterial infection in chronic obstructive pulmonary disease. A study of stable and exacerbated outpatients using the protected specimen brush. Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 1):1316–1320. doi: 10.1164/ajrccm.152.4.7551388. [DOI] [PubMed] [Google Scholar]
  52. Moser K. M., Luchsinger P. C., Adamson J. S., McMahon S. M., Schlueter D. P., Spivack M., Weg J. G. Respiratory stimulation with intravenous doxapram in respiratory failure. A double-blind co-operative study. N Engl J Med. 1973 Mar 1;288(9):427–431. doi: 10.1056/NEJM197303012880901. [DOI] [PubMed] [Google Scholar]
  53. Mushlin A. I., Black E. R., Connolly C. A., Buonaccorso K. M., Eberly S. W. The necessary length of hospital stay for chronic pulmonary disease. JAMA. 1991 Jul 3;266(1):80–83. [PubMed] [Google Scholar]
  54. Nava S., Ambrosino N., Clini E., Prato M., Orlando G., Vitacca M., Brigada P., Fracchia C., Rubini F. Noninvasive mechanical ventilation in the weaning of patients with respiratory failure due to chronic obstructive pulmonary disease. A randomized, controlled trial. Ann Intern Med. 1998 May 1;128(9):721–728. doi: 10.7326/0003-4819-128-9-199805010-00004. [DOI] [PubMed] [Google Scholar]
  55. Newton D. A., Stephenson A. Effect of physiotherapy on pulmonary function. A laboratory study. Lancet. 1978 Jul 29;2(8083):228–229. doi: 10.1016/s0140-6736(78)91742-7. [DOI] [PubMed] [Google Scholar]
  56. Nichol K. L., Baken L., Wuorenma J., Nelson A. The health and economic benefits associated with pneumococcal vaccination of elderly persons with chronic lung disease. Arch Intern Med. 1999 Nov 8;159(20):2437–2442. doi: 10.1001/archinte.159.20.2437. [DOI] [PubMed] [Google Scholar]
  57. Niewoehner D. E., Erbland M. L., Deupree R. H., Collins D., Gross N. J., Light R. W., Anderson P., Morgan N. A. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. N Engl J Med. 1999 Jun 24;340(25):1941–1947. doi: 10.1056/NEJM199906243402502. [DOI] [PubMed] [Google Scholar]
  58. O'Driscoll B. R., Taylor R. J., Horsley M. G., Chambers D. K., Bernstein A. Nebulised salbutamol with and without ipratropium bromide in acute airflow obstruction. Lancet. 1989 Jun 24;1(8652):1418–1420. doi: 10.1016/s0140-6736(89)90126-8. [DOI] [PubMed] [Google Scholar]
  59. Paggiaro P. L., Dahle R., Bakran I., Frith L., Hollingworth K., Efthimiou J. Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease. International COPD Study Group. Lancet. 1998 Mar 14;351(9105):773–780. doi: 10.1016/s0140-6736(97)03471-5. [DOI] [PubMed] [Google Scholar]
  60. Patrick D. M., Dales R. E., Stark R. M., Laliberte G., Dickinson G. Severe exacerbations of COPD and asthma. Incremental benefit of adding ipratropium to usual therapy. Chest. 1990 Aug;98(2):295–297. doi: 10.1378/chest.98.2.295. [DOI] [PubMed] [Google Scholar]
  61. Pauwels R. A., Löfdahl C. G., Laitinen L. A., Schouten J. P., Postma D. S., Pride N. B., Ohlsson S. V. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med. 1999 Jun 24;340(25):1948–1953. doi: 10.1056/NEJM199906243402503. [DOI] [PubMed] [Google Scholar]
  62. Peach H., Pathy M. S. Follow-up study of disability among elderly patients discharged from hospital with exacerbations of chronic bronchitis. Thorax. 1981 Aug;36(8):585–589. doi: 10.1136/thx.36.8.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Peralta J., Poderoso J. J., Corazza C., Fernández M., Guerreiro R. B., Wiemeyer J. C. Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. Arzneimittelforschung. 1987 Aug;37(8):969–971. [PubMed] [Google Scholar]
  64. Petersen E. S., Esmann V., Honcke P., Munkner C. A controlled study of the effect of treatment on chronic bronchitis. An evaluation using pulmonary function tests. Acta Med Scand. 1967 Sep;182(3):293–305. doi: 10.1111/j.0954-6820.1967.tb11527.x. [DOI] [PubMed] [Google Scholar]
  65. Pines A., Raafat H., Plucinski K., Greenfield J. S., Solari M. Antibiotic regimens in severe and acute purulent exacerbations of chronic bronchitis. Br Med J. 1968 Jun 22;2(5607):735–738. doi: 10.1136/bmj.2.5607.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Plant P. K., Owen J. L., Elliott M. W. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet. 2000 Jun 3;355(9219):1931–1935. doi: 10.1016/s0140-6736(00)02323-0. [DOI] [PubMed] [Google Scholar]
  67. Plant P. K., Owen J. L., Elliott M. W. Non-invasive ventilation in acute exacerbations of chronic obstructive pulmonary disease: long term survival and predictors of in-hospital outcome. Thorax. 2001 Sep;56(9):708–712. doi: 10.1136/thorax.56.9.708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Plant P. K., Owen J. L., Elliott M. W. One year period prevalence study of respiratory acidosis in acute exacerbations of COPD: implications for the provision of non-invasive ventilation and oxygen administration. Thorax. 2000 Jul;55(7):550–554. doi: 10.1136/thorax.55.7.550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Poole P. J., Black P. N. Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review. BMJ. 2001 May 26;322(7297):1271–1274. doi: 10.1136/bmj.322.7297.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Poole P. J., Chacko E., Wood-Baker R. W., Cates C. J. Influenza vaccine for patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2000;(4):CD002733–CD002733. doi: 10.1002/14651858.CD002733. [DOI] [PubMed] [Google Scholar]
  71. Rebuck A. S., Chapman K. R., Abboud R., Pare P. D., Kreisman H., Wolkove N., Vickerson F. Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room. Am J Med. 1987 Jan;82(1):59–64. doi: 10.1016/0002-9343(87)90378-0. [DOI] [PubMed] [Google Scholar]
  72. Roberts C. M., Lowe D., Bucknall C. E., Ryland I., Kelly Y., Pearson M. G. Clinical audit indicators of outcome following admission to hospital with acute exacerbation of chronic obstructive pulmonary disease. Thorax. 2002 Feb;57(2):137–141. doi: 10.1136/thorax.57.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Roberts C. M., Ryland I., Lowe D., Kelly Y., Bucknall C. E., Pearson M. G., Audit Sub-committee of the Standards of Care Committee, British Thoracic Society. Clinical Effectiveness and Evaluation Unit, Royal College of Physicians Audit of acute admissions of COPD: standards of care and management in the hospital setting. Eur Respir J. 2001 Mar;17(3):343–349. doi: 10.1183/09031936.01.17303430. [DOI] [PubMed] [Google Scholar]
  74. Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest. 2000 May;117(5 Suppl 2):398S–401S. doi: 10.1378/chest.117.5_suppl_2.398s. [DOI] [PubMed] [Google Scholar]
  75. Sachs A. P., Koëter G. H., Groenier K. H., van der Waaij D., Schiphuis J., Meyboom-de Jong B. Changes in symptoms, peak expiratory flow, and sputum flora during treatment with antibiotics of exacerbations in patients with chronic obstructive pulmonary disease in general practice. Thorax. 1995 Jul;50(7):758–763. doi: 10.1136/thx.50.7.758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Saetta M., Di Stefano A., Maestrelli P., Turato G., Ruggieri M. P., Roggeri A., Calcagni P., Mapp C. E., Ciaccia A., Fabbri L. M. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1646–1652. doi: 10.1164/ajrccm.150.6.7952628. [DOI] [PubMed] [Google Scholar]
  77. Saint S., Bent S., Vittinghoff E., Grady D. Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA. 1995 Mar 22;273(12):957–960. [PubMed] [Google Scholar]
  78. Scanlon P. D., Connett J. E., Waller L. A., Altose M. D., Bailey W. C., Buist A. S., Tashkin D. P., Lung Health Study Research Group Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):381–390. doi: 10.1164/ajrccm.161.2.9901044. [DOI] [PubMed] [Google Scholar]
  79. Schwartz J. Air pollution and hospital admissions for the elderly in Detroit, Michigan. Am J Respir Crit Care Med. 1994 Sep;150(3):648–655. doi: 10.1164/ajrccm.150.3.8087333. [DOI] [PubMed] [Google Scholar]
  80. Seemungal T. A., Donaldson G. C., Bhowmik A., Jeffries D. J., Wedzicha J. A. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 May;161(5):1608–1613. doi: 10.1164/ajrccm.161.5.9908022. [DOI] [PubMed] [Google Scholar]
  81. Seemungal T. A., Donaldson G. C., Paul E. A., Bestall J. C., Jeffries D. J., Wedzicha J. A. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1418–1422. doi: 10.1164/ajrccm.157.5.9709032. [DOI] [PubMed] [Google Scholar]
  82. Seemungal T. A., Harper-Owen R., Bhowmik A., Jeffries D. J., Wedzicha J. A. Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease. Eur Respir J. 2000 Oct;16(4):677–683. doi: 10.1034/j.1399-3003.2000.16d19.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Seneff M. G., Wagner D. P., Wagner R. P., Zimmerman J. E., Knaus W. A. Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. JAMA. 1995 Dec 20;274(23):1852–1857. [PubMed] [Google Scholar]
  84. Shrestha M., O'Brien T., Haddox R., Gourlay H. S., Reed G. Decreased duration of emergency department treatment of chronic obstructive pulmonary disease exacerbations with the addition of ipratropium bromide to beta-agonist therapy. Ann Emerg Med. 1991 Nov;20(11):1206–1209. doi: 10.1016/s0196-0644(05)81472-6. [DOI] [PubMed] [Google Scholar]
  85. Sin D. D., Tu J. V. Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 Aug 15;164(4):580–584. doi: 10.1164/ajrccm.164.4.2009033. [DOI] [PubMed] [Google Scholar]
  86. Skwarska E., Cohen G., Skwarski K. M., Lamb C., Bushell D., Parker S., MacNee W. Randomized controlled trial of supported discharge in patients with exacerbations of chronic obstructive pulmonary disease. Thorax. 2000 Nov;55(11):907–912. doi: 10.1136/thorax.55.11.907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Soo Hoo G. W., Santiago S., Williams A. J. Nasal mechanical ventilation for hypercapnic respiratory failure in chronic obstructive pulmonary disease: determinants of success and failure. Crit Care Med. 1994 Aug;22(8):1253–1261. doi: 10.1097/00003246-199408000-00009. [DOI] [PubMed] [Google Scholar]
  88. Soriano J. B., Maier W. C., Egger P., Visick G., Thakrar B., Sykes J., Pride N. B. Recent trends in physician diagnosed COPD in women and men in the UK. Thorax. 2000 Sep;55(9):789–794. doi: 10.1136/thorax.55.9.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Spencer S., Calverley P. M., Sherwood Burge P., Jones P. W., ISOLDE Study Group. Inhaled Steroids in Obstructive Lung Disease Health status deterioration in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 Jan;163(1):122–128. doi: 10.1164/ajrccm.163.1.2005009. [DOI] [PubMed] [Google Scholar]
  90. Stewart D. G., Drake D. F., Robertson C., Marwitz J. H., Kreutzer J. S., Cifu D. X. Benefits of an inpatient pulmonary rehabilitation program: a prospective analysis. Arch Phys Med Rehabil. 2001 Mar;82(3):347–352. doi: 10.1053/apmr.2001.20838. [DOI] [PubMed] [Google Scholar]
  91. Stey C., Steurer J., Bachmann S., Medici T. C., Tramèr M. R. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J. 2000 Aug;16(2):253–262. doi: 10.1034/j.1399-3003.2000.16b12.x. [DOI] [PubMed] [Google Scholar]
  92. Stockley R. A., O'Brien C., Pye A., Hill S. L. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest. 2000 Jun;117(6):1638–1645. doi: 10.1378/chest.117.6.1638. [DOI] [PubMed] [Google Scholar]
  93. Swinburn C. R., Mould H., Stone T. N., Corris P. A., Gibson G. J. Symptomatic benefit of supplemental oxygen in hypoxemic patients with chronic lung disease. Am Rev Respir Dis. 1991 May;143(5 Pt 1):913–915. doi: 10.1164/ajrccm/143.5_Pt_1.913. [DOI] [PubMed] [Google Scholar]
  94. Thompson W. H., Nielson C. P., Carvalho P., Charan N. B., Crowley J. J. Controlled trial of oral prednisone in outpatients with acute COPD exacerbation. Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):407–412. doi: 10.1164/ajrccm.154.2.8756814. [DOI] [PubMed] [Google Scholar]
  95. Tsai T. W., Gallagher E. J., Lombardi G., Gennis P., Carter W. Guidelines for the selective ordering of admission chest radiography in adult obstructive airway disease. Ann Emerg Med. 1993 Dec;22(12):1854–1858. doi: 10.1016/s0196-0644(05)80413-5. [DOI] [PubMed] [Google Scholar]
  96. Turner M. O., Patel A., Ginsburg S., FitzGerald J. M. Bronchodilator delivery in acute airflow obstruction. A meta-analysis. Arch Intern Med. 1997 Aug 11;157(15):1736–1744. [PubMed] [Google Scholar]
  97. Vestbo J., Sørensen T., Lange P., Brix A., Torre P., Viskum K. Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 1999 May 29;353(9167):1819–1823. doi: 10.1016/s0140-6736(98)10019-3. [DOI] [PubMed] [Google Scholar]
  98. Vincken W., van Noord J. A., Greefhorst A. P. M., Bantje Th A., Kesten S., Korducki L., Cornelissen P. J. G., Dutch/Belgian Tiotropium Study Group Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur Respir J. 2002 Feb;19(2):209–216. doi: 10.1183/09031936.02.00238702. [DOI] [PubMed] [Google Scholar]
  99. Warrell D. A., Edwards R. H., Godfrey S., Jones N. L. Effect of controlled oxygen therapy on arterial blood gases in acute respiratory failure. Br Med J. 1970 May 23;1(5707):452–455. doi: 10.1136/bmj.2.5707.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Weir D. C., Bale G. A., Bright P., Sherwood Burge P. A double-blind placebo-controlled study of the effect of inhaled beclomethasone dipropionate for 2 years in patients with nonasthmatic chronic obstructive pulmonary disease. Clin Exp Allergy. 1999 Jun;29 (Suppl 2):125–128. doi: 10.1046/j.1365-2222.1999.00021.x. [DOI] [PubMed] [Google Scholar]
  101. Wollmer P., Ursing K., Midgren B., Eriksson L. Inefficiency of chest percussion in the physical therapy of chronic bronchitis. Eur J Respir Dis. 1985 Apr;66(4):233–239. [PubMed] [Google Scholar]
  102. Wysocki M., Tric L., Wolff M. A., Gertner J., Millet H., Herman B. Noninvasive pressure support ventilation in patients with acute respiratory failure. Chest. 1993 Mar;103(3):907–913. doi: 10.1378/chest.103.3.907. [DOI] [PubMed] [Google Scholar]
  103. Young P., Dewse M., Fergusson W., Kolbe J. Improvements in outcomes for chronic obstructive pulmonary disease (COPD) attributable to a hospital-based respiratory rehabilitation programme. Aust N Z J Med. 1999 Feb;29(1):59–65. doi: 10.1111/j.1445-5994.1999.tb01589.x. [DOI] [PubMed] [Google Scholar]
  104. van Grunsven P. M., van Schayck C. P., Derenne J. P., Kerstjens H. A., Renkema T. E., Postma D. S., Similowski T., Akkermans R. P., Pasker-de Jong P. C., Dekhuijzen P. N. Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis. Thorax. 1999 Jan;54(1):7–14. doi: 10.1136/thx.54.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]

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