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. 1982 Apr;21(4):655–660. doi: 10.1128/aac.21.4.655

Mutational Enzymatic Resistance of Enterobacter Species to Beta-Lactam Antibiotics

Mary F Lampe 1,†, Barbara J Allan 2, Barbara H Minshew 3, John C Sherris 1
PMCID: PMC181960  PMID: 6979311

Abstract

Mutants with enhanced β-lactam resistance were selected from strains of Enterobacter cloacae and E. aerogenes by using three antibiotics. High-level β-lactamase-producing mutants had similar degrees of increased resistance, enzyme substrate profiles, and isoelectric (pI) values irrespective of the selective agent. Reverse mutants from a resistant E. cloacae mutant regained the susceptibility pattern originally exhibited by the wild type, or were of enhanced susceptibility, and no longer expressed increased β-lactamase production. β-Lactamases of the mutants were similar in pI values to the wild-type enzyme. The increased resistance of the mutants therefore appeared to be accounted for by increased β-lactamase production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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