Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1984 Feb;25(2):187–190. doi: 10.1128/aac.25.2.187

Plasmid-mediated tetracycline resistance in Haemophilus ducreyi.

W L Albritton, I W Maclean, L A Slaney, A R Ronald, H G Deneer
PMCID: PMC185471  PMID: 6324665

Abstract

Clinical isolates of Haemophilus ducreyi were shown to be resistant to tetracycline. Resistance was associated in some strains with a 30-megadalton plasmid capable of transferring resistance in conjugative matings with other strains of H. ducreyi and other species of Haemophilus. Restriction endonuclease digestion patterns suggest a relationship between H. ducreyi plasmids and other tetracycline resistance plasmids in Haemophilus. The presence of plasmid-mediated resistance to the tetracyclines limits the use of these agents for the treatment of chancroid.

Full text

PDF
187

Images in this article

188Image
on p.188
189Image
on p.189

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASIN J. Chancroid; a report of 1,402 cases. Am J Syph Gonorrhea Vener Dis. 1952 Sep;36(5):483–487. [PubMed] [Google Scholar]
  2. Albritton W. L., Bendler J. W., Setlow J. K. Plasmid transformation in Haemophilus influenzae. J Bacteriol. 1981 Feb;145(2):1099–1101. doi: 10.1128/jb.145.2.1099-1101.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Albritton W. L., Brunton J. L., Meier M., Bowman M. N., Slaney L. A. Haemophilus influenzae: comparison of respiratory tract isolates with genitourinary tract isolates. J Clin Microbiol. 1982 Nov;16(5):826–831. doi: 10.1128/jcm.16.5.826-831.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Albritton W. L., Brunton J. L., Slaney L., MacLean I. Plasmid-mediated sulfonamide resistance in Haemophilus ducreyi. Antimicrob Agents Chemother. 1982 Jan;21(1):159–165. doi: 10.1128/aac.21.1.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brunton J. L., Maclean I., Ronald A. R., Albritton W. L. Plasmid-mediated ampicillin resistance in Haemophilus ducreyi. Antimicrob Agents Chemother. 1979 Feb;15(2):294–299. doi: 10.1128/aac.15.2.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brunton J., Bennett P., Grinsted J. Molecular nature of a plasmid specifying beta-lactamase production in Haemophilus ducreyi. J Bacteriol. 1981 Dec;148(3):788–795. doi: 10.1128/jb.148.3.788-795.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Brunton J., Meier M., Ehrman N., Maclean I., Slaney L., Albritton W. L. Molecular epidemiology of beta-lactamase-specifying plasmids of Haemophilus ducreyi. Antimicrob Agents Chemother. 1982 Jun;21(6):857–863. doi: 10.1128/aac.21.6.857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Elwell L. P., De Graaff J., Seibert D., Falkow S. Plasmid-linked ampicillin resistance in haempohilus influenza type b. Infect Immun. 1975 Aug;12(2):404–410. doi: 10.1128/iai.12.2.404-410.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Elwell L. P., Saunders J. R., Richmond M. H., Falkow S. Relationships among some R plasmids found in Haemophilus influenzae. J Bacteriol. 1977 Jul;131(1):356–362. doi: 10.1128/jb.131.1.356-362.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fast M. V., Nsanze H., D'Costa L. J., Karasira P., Maclean I. W., Piot P., Albritton W. L., Ronald A. R. Antimicrobial therapy of chancroid: an evaluation of five treatment regimens correlated with in vitro sensitivity. Sex Transm Dis. 1983 Jan-Mar;10(1):1–6. [PubMed] [Google Scholar]
  11. Hammond G. W., Lian C. J., Wilt J. C., Ronald A. R. Antimicrobial susceptibility of Haemophilus ducreyi. Antimicrob Agents Chemother. 1978 Apr;13(4):608–612. doi: 10.1128/aac.13.4.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jahn G., Laufs R., Kaulfers P. M., Kolenda H. Molecular nature of two Haemophilus influenzae R factors containing resistances and the multiple integration of drug resistance transposons. J Bacteriol. 1979 May;138(2):584–597. doi: 10.1128/jb.138.2.584-597.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jorgensen R. A., Berg D. E., Allet B., Reznikoff W. S. Restriction enzyme cleavage map of Tn10, a transposon which encodes tetracycline resistance. J Bacteriol. 1979 Jan;137(1):681–685. doi: 10.1128/jb.137.1.681-685.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kaulfers P. M., Laufs R., Jahn G. Molecular properties of transmissible R factors of Haemophilus influenzae determing tetracycline resistance. J Gen Microbiol. 1978 Apr;105(2):243–252. doi: 10.1099/00221287-105-2-243. [DOI] [PubMed] [Google Scholar]
  15. Kerber R. E., Rowe C. E., Gilbert K. R. Treatment of chancroid. A comparison of tetracycline and sulfisoxazole. Arch Dermatol. 1969 Nov;100(5):604–607. [PubMed] [Google Scholar]
  16. Laufs R., Kaulfers P. M., Jahn G., Teschner U. Molecular characterization of a small Haemophilus influenzae plasmid specifying beta-lactamase and its relationship to R factors from Neisseria gonorrhoeae. J Gen Microbiol. 1979 Mar;111(1):223–231. doi: 10.1099/00221287-111-1-223. [DOI] [PubMed] [Google Scholar]
  17. Laufs R., Riess F. C., Jahn G., Fock R., Kaulfers P. M. Origin of Haemophilus influenzae R factors. J Bacteriol. 1981 Aug;147(2):563–568. doi: 10.1128/jb.147.2.563-568.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Roberts M. C., Smith A. L. Molecular characterization of "plasmid-free" antibiotic-resistant Haemophilus influenzae. J Bacteriol. 1980 Oct;144(1):476–479. doi: 10.1128/jb.144.1.476-479.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sanson-Le Pors M. J., Casin I. M., Ortenberg M., Perol Y. Detection of chloramphenicol acetyltransferase (CAT) activity in a strain of Haemophilus ducreyi. Ann Microbiol (Paris) 1982 Sep-Oct;133(2):311–315. [PubMed] [Google Scholar]
  20. Stuy J. H. Chromosomally integrated conjugative plasmids are common in antibiotic-resistant Haemophilus influenzae. J Bacteriol. 1980 Jun;142(3):925–930. doi: 10.1128/jb.142.3.925-930.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Totten P. A., Handsfield H. H., Peters D., Holmes K. K., Falkow S. Characterization of ampicillin resistance plasmids from Haemophilus ducreyi. Antimicrob Agents Chemother. 1982 Apr;21(4):622–627. doi: 10.1128/aac.21.4.622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. WILLCOX R. R. The treatment of chancroid. Br J Clin Pract. 1963 Aug 8;17:455–460. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES