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. 1990 Jul;137(1):135–147.

Ovarian Adenocarcinomas Express fms-Complementary Transcripts and fms Antigen, Often with Coexpression of CSF-1

Barry M Kacinski, Darryl Carter, Khushbakhat Mittal, Lisa D Yee, Kimberly A Scata, Lisa Donofrio, Setsuko K Chambers, Kuan-l Wang, Teresa Yang-Feng, L R Rohrschneider, Victoria M Rothwell
PMCID: PMC1877699  PMID: 1695482

Abstract

In earlier studies of oncogene expression in ovarian and endometrial neoplasms, the authors reported that high tumor levels of fms-complementary transcripts correlate with high histologic grade and advanced clinical stage presentations. In this communication, they pursue these initial clinicopathologic investigations to demonstrate by in situ hybridization and immunohistochemistry that malignant epithelial cells of 14 of 14 invasive adenocarcinomas of the ovary express fms-complementary transcripts. By Northern blotting and by reverse transcription, followed by polymerase chain reaction amplification, the authors also were able to demonstrate fms transcript expression in several ovarian and endometrial carcinoma-derived cell lines. Because about half (6/14) of the invasive adenocarcinoma specimens were shown to coexpress fms and colony-stimulating factor 1, the authors propose that the expression of this lymphohematopoietic cytokine and its receptor by ovarian adenocarcinomas could contribute totheir proliferative and invasive characteristics in vivo.

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