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. 1976 Dec 4;115(11):1096–1099.

Localisation du site de l'infection urinaire chez l'enfant par la recherche de bactéries recouvertes d'anticorps

Localization of the site of urinary infection in children by an investigation of antibody-covered bacteria

S Montplaisir, P P Côté, B Martineau, A J Roche, J G Mongeau, P Robitaille
PMCID: PMC1878893  PMID: 793701

Abstract

The demonstration by immuno-fluorescence of antibodies on the surface of urinary bacteria, a new method of determining the site of a urinary tract infection, was found to be as valuable in children as it is in adults. A clear correlation exists between a positive test result and renal parenchymal infection on one hand, and a negative result and lower urinary tract infection on the other. Moreover, immunoglobulins were still detectable in original positive urine samples that had been standing at 4degrees C for 7 weeks. The constant finding of IgA on bacteria suggests a particular synthesis for this class of immunoglobulin. A pathophysiologic role for complement would appear to be excluded by the facts that the serum concentrations of C3 were normal and that C3 was invariably absent from the bacterial surface.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beregi E., Hamvas A., Rényi-Vámos F. Immunhistological studies in chronic pyelonephritis. Clin Nephrol. 1974;2(3):113–115. [PubMed] [Google Scholar]
  2. Cohen M. Urinary tract infections in children. I. Females aged 2 through 14, first two infections. Pediatrics. 1972 Aug;50(2):271–278. [PubMed] [Google Scholar]
  3. Cotran R. S. Immunopathology of pyelonephritis: studies on the pathogenesis and diagnosis of the renal lesion. Verh Dtsch Ges Inn Med. 1974;80:841–848. doi: 10.1007/978-3-642-85449-1_243. [DOI] [PubMed] [Google Scholar]
  4. Dodge W. F., West E. F., Fras P. A., Travis L. B. Detection of bacteriuria in children. J Pediatr. 1969 Jan;74(1):107–110. doi: 10.1016/s0022-3476(69)80015-6. [DOI] [PubMed] [Google Scholar]
  5. Fairley K. F., Bond A. G., Brown R. B., Habersberger P. Simple test to determine the site of urinary-tract infection. Lancet. 1967 Aug 26;2(7513):427–428. doi: 10.1016/s0140-6736(67)90849-5. [DOI] [PubMed] [Google Scholar]
  6. Jodal U., Lindberg U., Lincoln K. Level diagnosis of symptomatic urinary tract infections in childhood. Acta Paediatr Scand. 1975 Mar;64(2):201–208. doi: 10.1111/j.1651-2227.1975.tb03822.x. [DOI] [PubMed] [Google Scholar]
  7. Jones S. R., Smith J. W., Sanford J. P. Localization of urinary-tract infections by detection of antibody-coated bacteria in urine sediment. N Engl J Med. 1974 Mar 14;290(11):591–593. doi: 10.1056/NEJM197403142901103. [DOI] [PubMed] [Google Scholar]
  8. KUNIN C. M., ZACHA E., PAQUIN A. J., Jr Urinary-tract infections in schoolchildren. I. Prevalence of bacteriuria and associated urologic findings. N Engl J Med. 1962 Jun 21;266:1287–1296. doi: 10.1056/NEJM196206212662501. [DOI] [PubMed] [Google Scholar]
  9. Kunin C. M. Emergence of bacteriuria, proteinuria, and symptomatic urinary tract infections among a population of school girls followed for 7 years. Pediatrics. 1968 May;41(5):968–976. [PubMed] [Google Scholar]
  10. Lehmann J. D., Smith J. W., Miller T. E., Barnett J. A., Sanford J. P. Local immune response in experimental pyelonephritis. J Clin Invest. 1969 Nov;47(11):2541–2550. doi: 10.1172/JCI105936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ronald A. R., Cutler R. E., Turck M. Effect of bacteriuria on renal concentrating mechanisms. Ann Intern Med. 1969 Apr;70(4):723–733. doi: 10.7326/0003-4819-70-4-723. [DOI] [PubMed] [Google Scholar]
  12. Thomas V. L., Forland M., Shelokov A. Immunoglobulin levels and antibody-coated bacteria in urines from patients with urinary tract infections. Proc Soc Exp Biol Med. 1975 Apr;148(4):1198–1201. doi: 10.3181/00379727-148-38716. [DOI] [PubMed] [Google Scholar]
  13. Thomas V., Shelokov A., Forland M. Antibody-coated bacteria in the urine and the site of urinary-tract infection. N Engl J Med. 1974 Mar 14;290(11):588–590. doi: 10.1056/NEJM197403142901102. [DOI] [PubMed] [Google Scholar]
  14. Uttley W. S., Paxton J., Thistlethwaite D. Urinary concentrating ability and growth failure in urinary tract disorders. Arch Dis Child. 1972 Jun;47(253):436–441. doi: 10.1136/adc.47.253.436. [DOI] [PMC free article] [PubMed] [Google Scholar]

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