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. 1987 May;127(2):271–278.

Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice.

M Barral-Netto, L A de Freitas, Z A Andrade
PMCID: PMC1899741  PMID: 3495185

Abstract

Highly susceptible BALB/c mice became partially resistant to Leishmania mexicana amazonensis infection after intravenous immunization with solubilized homologous promastigote antigen. Immunized BALB/c mice exhibited mixed mononuclear cell reactions, with granulomatous inflammation, collagen deposition, and fibrinoid necrosis at the site of infection. In contrast, naive animals displayed a monomorphic picture composed of largely vacuolated and parasitized macrophages with areas of coagulative necrosis. Electron microscopy revealed an increased number of eosinophils, sometimes in close contact with parasitized macrophages, in immunized animals. These findings illustrate that histologic changes reflect host immune status in cutaneous leishmaniasis, and that susceptibility of BALB/c mice to L m amazonensis, although dependent on genetic background, can be artificially modified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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