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. 1981 Nov;105(2):97–106.

Comparison of histologic and immunologic heterogeneity of non-Hodgkin's lymphomas.

M J Borowitz, B P Croker, R S Metzgar
PMCID: PMC1903885  PMID: 6170233

Abstract

The lymphocyte surface marker phenotype in 11 selected cases of non-Hodgkin's lymphomas was determined with anti-immunoglobulin and mouse monoclonal antibodies against human lymphocyte antigens. A complement-mediated cell cytotoxicity assay on suspensions of the tumor cells was compared with an indirect immunoperoxidase technique on frozen tissue sections. Both methods gave good results in tumors with a uniform cell population, but the frozen section technique was superior in heterogeneous tumors. The six B-cell neoplasms were heterogeneous with respect to expression of surface immunoglobulin and Ia antigens. The five T-cell tumors were morphologically heterogeneous and also highly variable in their expression of different T-cell specific antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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