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. 1997 Oct;71(10):7960–7962. doi: 10.1128/jvi.71.10.7960-7962.1997

Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D.

W C Manning 1, X Paliard 1, S Zhou 1, M Pat Bland 1, A Y Lee 1, K Hong 1, C M Walker 1, J A Escobedo 1, V Dwarki 1
PMCID: PMC192154  PMID: 9311887

Abstract

Intramuscular injection of mice with an adeno-associated virus (AAV) vector expressing herpes simplex virus type 2 glycoprotein B led to the generation of both gB-specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes and anti-gB antibody. AAV-mediated immunization was more potent than plasmid DNA or protein in generating antibody responses.

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Selected References

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