Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1979 Feb;39(2):116–121. doi: 10.1038/bjc.1979.21

Serological aspects of rat tumour xenograft growth in athymic nude mice.

M V Pimm, R W Baldwin
PMCID: PMC2009841  PMID: 373782

Abstract

The serum of athymic nude mice bearing rat tumour xenografts has been examined for tumour-specific antigen. With a sarcoma and a hepatoma, tumour-specific antigen expression continued in xenograft growths, and sera of tumour-bearing mice contained free antigen, assayed by its ability to neutralise reactivity of tumour-immune rat sera against tumour target cells in an indirect membrane-immunofluorescence test. In contrast, no anti-rat antibody was detectable in sera of mice bearing the xenografts, or rejecting cells injected in admixture with BCG.

Full text

PDF
118

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin R. W., Barker C. R. Demonstration of tumour-specific humoral antibody against aminoazo dye-induced rat hepatomata. Br J Cancer. 1967 Dec;21(4):793–800. doi: 10.1038/bjc.1967.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baldwin R. W., Barker C. R. Tumour-specific antigenicity of aminoazo-dye-induced rat hepatomas. Int J Cancer. 1967 Jul 15;2(4):355–364. doi: 10.1002/ijc.2910020410. [DOI] [PubMed] [Google Scholar]
  3. Baldwin R. W., Pimm M. V. Influence of BCG infection on growth of 3-methylcholanthrene-induced rat sarcomas. Rev Eur Etud Clin Biol. 1971 Nov;16(9):875–881. [PubMed] [Google Scholar]
  4. Bowen J. G., Baldwin R. W. Isolation and characterization of tumour-specific antigen from the serum of rats bearing transplanted aminoazo dye-induced hepatomas. Transplantation. 1976 Mar;21(3):213–219. doi: 10.1097/00007890-197603000-00005. [DOI] [PubMed] [Google Scholar]
  5. Freedman V. H., Brown A. L., Klinger H. P., Shin S. I. Mass production of animal cells in nude mice with retention of cell specific markers. Exp Cell Res. 1976 Mar 1;98(1):143–151. doi: 10.1016/0014-4827(76)90473-0. [DOI] [PubMed] [Google Scholar]
  6. Houghton J. A., Taylor D. M. Growth characteristics of human colorectal tumours during serial passage in immune-deprived mice. Br J Cancer. 1978 Feb;37(2):213–223. doi: 10.1038/bjc.1978.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Houghton J. A., Taylor D. M. Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice. Br J Cancer. 1978 Feb;37(2):199–212. doi: 10.1038/bjc.1978.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Houghton P. J., Houghton J. A., Taylor D. M. Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts. Br J Cancer. 1977 Aug;36(2):206–214. doi: 10.1038/bjc.1977.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kameya T., Shimosato Y., Tumuraya M., Ohsawa N., Nomura T. Human gastric choriocarcinoma serially transplanted in nude mice. J Natl Cancer Inst. 1976 Feb;56(2):325–332. doi: 10.1093/jnci/56.2.325. [DOI] [PubMed] [Google Scholar]
  10. Kopper L., Steel G. G. The therapeutic response of three human tumor lines maintained in immune-suppressed mice. Cancer Res. 1975 Oct;35(10):2704–2713. [PubMed] [Google Scholar]
  11. Lamerton L. F., Steel G. G. Growth kinetics of human large bowel cancer growing in immune-deprived mice and some chemotherapeutic observations. Cancer. 1975 Dec;36(6 Suppl):2431–2436. doi: 10.1002/1097-0142(197512)36:6<2431::aid-cncr2820360625>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  12. Mach J. P., Carrel S., Merenda C., Sordat B., Cerottini J. C. In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice. Nature. 1974 Apr 19;248(5450):704–706. doi: 10.1038/248704a0. [DOI] [PubMed] [Google Scholar]
  13. Nordquist R. E., Anglin J. H., Lerner M. P. Antigen shedding by human breast-cancer cells in vitro and in vivo. Br J Cancer. 1978 May;37(5):776–779. doi: 10.1038/bjc.1978.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pickard R. G., Cobb L. M., Steel G. G. The growth kinetics of xenografts of human colorectal tumours in immune deprived mice. Br J Cancer. 1975 Jan;31(1):36–45. doi: 10.1038/bjc.1975.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pimm M. V., Baldwin R. W. BCG immunotherapy of rat tumours in athymic nude mice. Nature. 1975 Mar 6;254(5495):77–78. doi: 10.1038/254077a0. [DOI] [PubMed] [Google Scholar]
  16. Pimm M. V., Baldwin R. W. BCG treatment of human tumour xenografts in athymic nude mice. Br J Cancer. 1978 Dec;38(6):699–702. doi: 10.1038/bjc.1978.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Povlsen C. O., Fialkow P. J., Klein E., Klein G., Rygaard J., Wiener F. Growth and antigenic properties of a biopsy-derived Burkitt's lymphoma in thymus-less (nude) mice. Int J Cancer. 1973 Jan 15;11(1):30–39. doi: 10.1002/ijc.2910110105. [DOI] [PubMed] [Google Scholar]
  18. Povlsen C. O., Jacobsen G. K. Chemotherapy of a human malignant melanoma transplanted in the nude mouse. Cancer Res. 1975 Oct;35(10):2790–2796. [PubMed] [Google Scholar]
  19. Reeves B. R., Houghton J. A. Serial cytogenetic studies of human colonic tumour xenografts. Br J Cancer. 1978 Apr;37(4):612–619. doi: 10.1038/bjc.1978.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sonis S. T., Falcão R., MacLennan I. C. Assessment of drug sensitivity of human leukaemic myeloblasts. II. The toxic effects of cytosine arabinoside on 125IUdR-labelled human leukaemic myeloblasts in mice. Br J Cancer. 1977 Sep;36(3):307–312. doi: 10.1038/bjc.1977.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stutman Tumor development after polyoma infection in athymic nude mice. J Immunol. 1975 Apr;114(4):1213–1217. [PubMed] [Google Scholar]
  22. Tevethia S. S., Waneck G., Tevethia M. J. Immune response of athymic nude mice to papovavirus SV40 tumor-associated antigens. Int J Cancer. 1977 May 15;19(5):700–706. doi: 10.1002/ijc.2910190516. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES