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. 1982 Apr;45(4):588–597. doi: 10.1038/bjc.1982.96

Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.

J C Williams, B A Gusterson, R C Coombes
PMCID: PMC2010985  PMID: 7073949

Abstract

N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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