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British Journal of Cancer logoLink to British Journal of Cancer
. 1983 Feb;47(2):285–291. doi: 10.1038/bjc.1983.37

The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice.

R H Mole, D G Papworth, M J Corp
PMCID: PMC2011291  PMID: 6337614

Abstract

The form of the dose-response for induction of malignant diseases in vivo by ionizing radiation is not yet established in spite of its scientific interest and its practical importance. Considerably extended observations have confirmed that the dose-response for acute myeloid leukaemia induced in male CBA/H mice by X-ray exposure is highly curvilinear. The dose-response was well fitted by the expression aD2e-lambda D (D = dose) in agreement with induction at the cellular level in proportion to D2 over the whole dose range 0.25-6.0 Gy. The factor e-lambda D accounts for the inescapable concomitant inactivating action of the inducing irradiation. The quantitative aspects of induction of myeloid leukaemia by ionizing radiation are unlike the induction of genetic mutation or cell inactivation and suggest that interaction of two adjoining cells is an essential element in radiation leukaemogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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