Skip to main content
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1976 Dec;85(3):773–804.

The pathology of renal homograft rejection. A review.

D T Rowlands Jr, G S Hill, C M Zmijewski
PMCID: PMC2032660  PMID: 187063

Full text

PDF
774

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDRE J. A., SCHWARTZ R. S., MITUS W. J., DAMESHEK W. The morphologic responses of the lymphoid system to homografts. I. First and second set responses in normal rabbits. Blood. 1962 Mar;19:313–333. [PubMed] [Google Scholar]
  2. Amos B. Immunologic factors in organ transplantation. Am J Med. 1968 May;44(5):767–775. doi: 10.1016/0002-9343(68)90257-x. [DOI] [PubMed] [Google Scholar]
  3. Armstrong D., Balakrishnan S. L., Steger L., Yu B., Stenzel K. H. Cytomegalovirus infections with viremia following renal transplantation. Arch Intern Med. 1971 Jan;127(1):111–115. [PubMed] [Google Scholar]
  4. BILLINGHAM R. E., SILVERS W. K., WILSON D. B. FURTHER STUDIES ON ADOPTIVE TRANSFER OF SENSITIVITY TO SKIN HOMOGRAFTS. J Exp Med. 1963 Sep 1;118:397–420. doi: 10.1084/jem.118.3.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barker C. F., Billingham R. E. The role of regional lymphatics in the skin homograft response. Transplantation. 1967 Jul;5(4 Suppl):962–966. doi: 10.1097/00007890-196707001-00026. [DOI] [PubMed] [Google Scholar]
  6. Bossen E. H., Johnston W. W., Amatulli J., Rowlands D. T., Jr Exfoliative cytopathologic studies in organ transplantation. 3. The cytologic profile of urine during acute renal allograft rejection. Acta Cytol. 1970 Apr;14(4):176–181. [PubMed] [Google Scholar]
  7. Bossen E. H., Johnston W. W., Amatulli J., Rowlands D. T., Jr Exfoliative cytopathologic studies in organ transplantation. I. The cytologic diagnosis of cytomegalic inclusion disease in the urine of renal allograft recipients. Am J Clin Pathol. 1969 Sep;52(3):340–344. doi: 10.1093/ajcp/52.3.340. [DOI] [PubMed] [Google Scholar]
  8. Braun W. E., Banowsky L. H., Straffon R. A., Nakamoto S., Kiser W. S., Popowniak K. L., Hewitt C. B., Stewart B. H., Zelch J. V., Magalhaes R. L. Lymphocytes associated with renal transplantation. Report of 15 cases and review of the literature. Am J Med. 1974 Nov;57(5):714–729. doi: 10.1016/0002-9343(74)90845-6. [DOI] [PubMed] [Google Scholar]
  9. Busch G. J., Reynolds E. S., Galvanek E. G., Braun W. E., Dammin G. J. Human renal allografts. The role of vascular injury in early graft failure. Medicine (Baltimore) 1971 Jan;50(1):29–83. [PubMed] [Google Scholar]
  10. Clark E. A., Opelz G., Mickey M. R., Terasaki P. I. Evaluation of Belzer and Collins kidney-preservation methods. Lancet. 1973 Feb 17;1(7799):361–364. doi: 10.1016/s0140-6736(73)90142-6. [DOI] [PubMed] [Google Scholar]
  11. Cochrum K. C., Salvatierra O., Belzer F. O. Correlation between MLC stimulation and graft survival in living related and cadaver transplants. Ann Surg. 1974 Oct;180(4):617–622. doi: 10.1097/00000658-197410000-00027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Corson J. M. The pathologist and the kidney transplant. Pathol Annu. 1972;7:251–292. [PubMed] [Google Scholar]
  13. Crosson J. T., Wathen R. L., Raij L., Andersen R. C., Anderson W. R. Recurrence of idiopathic membranous nephropathy in a renal allograft. Arch Intern Med. 1975 Aug;135(8):1101–1106. [PubMed] [Google Scholar]
  14. DAUSSET J. Iso-leuco-anticorps. Acta Haematol. 1958 Jul-Oct;20(1-4):156–166. doi: 10.1159/000205478. [DOI] [PubMed] [Google Scholar]
  15. DEMPSTER W. J., HARRISON C. V., SHACKMAN R. REJECTION PROCESSES IN HUMAN HOMOTRANSPLANTED KIDNEYS. Br Med J. 1964 Oct 17;2(5415):969–976. doi: 10.1136/bmj.2.5415.969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. DEMPSTER W. J. Kidney homotransplantation. Br J Surg. 1953 Mar;40(163):447–465. doi: 10.1002/bjs.18004016309. [DOI] [PubMed] [Google Scholar]
  17. Dixon F. J., McPhaul J. J., Jr, Lerner R. Recurrence of glomerulonephritis in the transplanted kidney. Arch Intern Med. 1969 May;123(5):554–557. [PubMed] [Google Scholar]
  18. Dossetor J. B., Olson L. A. Evidence of latent sensitization to HL-A antigens. Transplantation. 1972 Jun;13(6):576–579. doi: 10.1097/00007890-197206000-00004. [DOI] [PubMed] [Google Scholar]
  19. ELKINS W. L. INVASION AND DESTRUCTION OF HOMOLOGOUS KIDNEY BY LOCALLY INOCULATED LYMPHOID CELLS. J Exp Med. 1964 Sep 1;120:329–348. doi: 10.1084/jem.120.3.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Elkins W. L., Guttmann R. D. Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes. Science. 1968 Mar 15;159(3820):1250–1251. doi: 10.1126/science.159.3820.1250. [DOI] [PubMed] [Google Scholar]
  21. Filo R. S., Dickson L. G., Suba E. A., Sell K. W. Immunologic injury induced by ex vivo perfusion of canine renal autografts. Surgery. 1974 Jul;76(1):88–100. [PubMed] [Google Scholar]
  22. Gibson T., Medawar P. B. The fate of skin homografts in man. J Anat. 1943 Jul;77(Pt 4):299–310.4. [PMC free article] [PubMed] [Google Scholar]
  23. Glassock R. J., Feldman D., Reynolds E. S., Dammin G. J., Merrill J. P. Human renal isografts: a clinical and pathologic analysis. Medicine (Baltimore) 1968 Sep;47(5):411–454. doi: 10.1097/00005792-196809000-00002. [DOI] [PubMed] [Google Scholar]
  24. HAMBURGER J., CROSNIER J., DORMONT J. OBSERVATIONS IN PATIENTS WITH A WELL-TOLERATED HOMOTRANSPLANTED KIDNEY: POSSIBILITY OF A NEW SECONDARY DISEASE. Ann N Y Acad Sci. 1964 Nov 30;120:558–577. doi: 10.1111/j.1749-6632.1964.tb34753.x. [DOI] [PubMed] [Google Scholar]
  25. HARROW B. R., SLOANE J. A., LIEBMAN N. C. Roentgenologic demonstration of renal papillary necrosis in sickle-cell trait. N Engl J Med. 1963 May 2;268:969–976. doi: 10.1056/NEJM196305022681802. [DOI] [PubMed] [Google Scholar]
  26. HILL R. B., Jr, ROWLANDS D. T., Jr, RIFKIND D. INFECTIOUS PULMONARY DISEASE IN PATIENTS RECEIVING IMMUNOSUPPRESSIVE THERAPY FOR ORGAN TRANSPLANTATION. N Engl J Med. 1964 Nov 12;271:1021–1027. doi: 10.1056/NEJM196411122712001. [DOI] [PubMed] [Google Scholar]
  27. HOROWITZ R. E., BURROWS L., PARONETTO F., DREILLING D., KARK A. E. IMMUNOLOGIC OBSERVATIONS ON HOMOGRAFTS. II. THE CANINE KIDNEY. Transplantation. 1965 May;3:318–325. doi: 10.1097/00007890-196505000-00002. [DOI] [PubMed] [Google Scholar]
  28. Hamburger J., Berger J., Hinglais N., Descamps B. New insights into the pathogenesis of glomerulonephritis afforded by the study of renal allografts. Clin Nephrol. 1973 Jan-Feb;1(1):3–7. [PubMed] [Google Scholar]
  29. Hill G. S., Light J. A., Perloff L. J. Perfusion-related injury in renal transplantation. Surgery. 1976 Apr;79(4):440–447. [PubMed] [Google Scholar]
  30. Kissmeyer-Nielsen F., Olsen S., Petersen V. P., Fjeldborg O. Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells. Lancet. 1966 Sep 24;2(7465):662–665. doi: 10.1016/s0140-6736(66)92829-7. [DOI] [PubMed] [Google Scholar]
  31. Light J. A., Hill G. S. Acute tubular necrosis in a renal transplant recipient. Complication from drip-infusion excretory urography. JAMA. 1975 Jun 23;232(12):1267–1268. [PubMed] [Google Scholar]
  32. Light J. A., Perloff L. J., Etheredge E. E., Hill G., Spees E. K. Adverse effects of meglumine diatrizoate on renal function in the early post-transplant period. Transplantation. 1975 Nov;20(5):404–409. doi: 10.1097/00007890-197511000-00008. [DOI] [PubMed] [Google Scholar]
  33. Lindquist R. R., Guttmann R. D., Merrill J. P., Dammin G. J. Human renal allografts. Interpretation of morphologic and immunohistochemical observations. Am J Pathol. 1968 Nov;53(5):851–881. [PMC free article] [PubMed] [Google Scholar]
  34. Lopez C., Simmons R. L., Mauer S. M., Najarian J. S., Good R. A., Gentry S. Association of renal allograft rejection with virus infections. Am J Med. 1974 Mar;56(3):280–289. doi: 10.1016/0002-9343(74)90609-3. [DOI] [PubMed] [Google Scholar]
  35. MEDAWAR P. B. The homograft reaction. Proc R Soc Lond B Biol Sci. 1958 Dec 4;149(935):145–166. doi: 10.1098/rspb.1958.0058. [DOI] [PubMed] [Google Scholar]
  36. MICHON L., HAMBURGER J., OECONOMOS N., DELINOTTE P., RICHET G., VAYSSE J., ANTOINE B. Une tentative de transplantation rénale chez l'homme: aspects médicauxét biologiques. Presse Med. 1953 Nov 4;61(70):1419–1423. [PubMed] [Google Scholar]
  37. Marshall V. Premalignant and malignant skin tumours in immunosuppressed patients. Transplantation. 1974 Mar;17(3):272–275. doi: 10.1097/00007890-197403000-00006. [DOI] [PubMed] [Google Scholar]
  38. Mathew T. H., Mathews D. C., Hobbs J. B., Kincaid-Smith P. Glomerular lesions after renal transplantation. Am J Med. 1975 Aug;59(2):177–190. doi: 10.1016/0002-9343(75)90352-6. [DOI] [PubMed] [Google Scholar]
  39. Medawar P. B. A second study of the behaviour and fate of skin homografts in rabbits: A Report to the War Wounds Committee of the Medical Research Council. J Anat. 1945 Oct;79(Pt 4):157–176.4. [PMC free article] [PubMed] [Google Scholar]
  40. Medawar P. B. The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the War Wounds Committee of the Medical Research Council. J Anat. 1944 Oct;78(Pt 5):176–199. [PMC free article] [PubMed] [Google Scholar]
  41. Milgrom F., Litvak B. I., Kano K., Witebsky E. Humoral antibodies in renal homograft. JAMA. 1966 Oct 17;198(3):226–230. [PubMed] [Google Scholar]
  42. Myburgh J. A., Cohen I., Gecelter L., Meyers A. M., Abrahams C., Furman K. I., Goldberg B., van Blerk P. J. Hyperacute rejection in human-kidney allografts-shwartzman or arthus reaction? N Engl J Med. 1969 Jul 17;281(3):131–135. doi: 10.1056/NEJM196907172810305. [DOI] [PubMed] [Google Scholar]
  43. Opelz G., Mickey M. R., Terasaki P. I. HL-A and kidney transplants: reexamination. Transplantation. 1974 Apr;17(4):371–382. doi: 10.1097/00007890-197404000-00006. [DOI] [PubMed] [Google Scholar]
  44. PAYNE R., ROLFS M. R. Fetomaternal leukocyte incompatibility. J Clin Invest. 1958 Dec;37(12):1756–1763. doi: 10.1172/JCI103768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. PORTER K. A. MORPHOLOGICAL ASPECTS OF RENAL HOMOGRAFT REJECTION. Br Med Bull. 1965 May;21:171–175. doi: 10.1093/oxfordjournals.bmb.a070388. [DOI] [PubMed] [Google Scholar]
  46. Penn I., Starzl T. E. A summary of the status of de novo cancer in transplant recipients. Transplant Proc. 1972 Dec;4(4):719–732. [PubMed] [Google Scholar]
  47. Peterson P. A., Cunningham B. A., Berggård I., Edelman G. M. 2 -Microglobulin--a free immunoglobulin domain. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1697–1701. doi: 10.1073/pnas.69.7.1697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Porter K. A., Andres G. A., Calder M. W., Dossetor J. B., Hsu K. C., Rendall J. M., Seegal B. C., Starzl T. E. Human renal transplants. II. Immunofluorescent and immunoferritin studies. Lab Invest. 1968 Feb;18(2):159–171. [PubMed] [Google Scholar]
  49. Porter K. A., Dossetor J. B., Marchioro T. L., Peart W. S., Rendall J. M., Starzl T. E., Terasaki P. I. Human renal transplants. I. Glomerular changes. Lab Invest. 1967 Jan;16(1):153–181. [PubMed] [Google Scholar]
  50. RIFKIND D., STARZL T. E., MARCHIORO T. L., WADDELL W. R., ROWLANDS D. T., Jr, HILL R. B., Jr TRANSPLANTATION PNEUMONIA. JAMA. 1964 Sep 14;189:808–812. doi: 10.1001/jama.1964.03070110010002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Rosenberg J. C., Hawkins E., Rector F. Mechanisms of immunological injury during antibody-mediated hyperacute rejection of renal heterografts. Transplantation. 1971 Feb;11(2):151–157. doi: 10.1097/00007890-197102000-00008. [DOI] [PubMed] [Google Scholar]
  52. Rowlands D. T., Crowle A. J., Russe H. P. Passively transferred delayed hypersensitivity reactions in mice and guinea-pigs. Int Arch Allergy Appl Immunol. 1965;28(6):328–335. doi: 10.1159/000229678. [DOI] [PubMed] [Google Scholar]
  53. Rowlands D. T., Jr, Bossen E. H. Immunological mechanisms of allograft rejection. Arch Intern Med. 1969 May;123(5):491–500. doi: 10.1001/archinte.123.5.491. [DOI] [PubMed] [Google Scholar]
  54. Rowlands D. T., Jr, Burkholder P. M., Bossen E. H., Lin H. H. Renal allografts in HL-A matched recipients. Light, immunofluorescence and electron microscopic studies. Am J Pathol. 1970 Nov;61(2):177–210. [PMC free article] [PubMed] [Google Scholar]
  55. STARZL T. E., BRITTAIN R. S., STONNINGTON O. G., COPPINGER W. R., WADDELL W. R. Renal transplantation in identical twins. Arch Surg. 1963 Apr;86:600–607. doi: 10.1001/archsurg.1963.01310100084013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. STARZL T. E., MARCHIORO T. L., HOLMES J. H., WADDELL W. R. THE INCIDENCE, CAUSE, AND SIGNIFICANCE OF IMMEDIATE AND DELAYED OLIGURIA OR ANURIA AFTER HUMAN RENAL TRANSPLANTATION. Surg Gynecol Obstet. 1964 Apr;118:819–827. [PMC free article] [PubMed] [Google Scholar]
  57. STARZL T. E., MARCHIORO T. L., RIFKIND D., HOLMES J. H., ROWLANDS D. T., Jr, WADDELL W. R. FACTORS IN SUCCESSFUL RENAL TRANSPLANTATION. Surgery. 1964 Jul;56:296–318. [PMC free article] [PubMed] [Google Scholar]
  58. STROBER S., GOWANS J. L. THE ROLE OF LYMPHOCYTES IN THE SENSITIZATION OF RATS TO RENAL HOMOGRAFTS. J Exp Med. 1965 Aug 1;122:347–360. doi: 10.1084/jem.122.2.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Simmons R. L., Thompson E. J., Kjellstrand C. M., Yunis E. J., Condie R. M., Mauer S. M., Buselmeier T. J., Najarian J. S. Parent-to-child and child-to-parent kidney transplants. Experience with 101 transplants at one centre. Lancet. 1976 Feb 14;1(7955):321–324. doi: 10.1016/s0140-6736(76)90082-9. [DOI] [PubMed] [Google Scholar]
  60. Starzl T. E., Boehmig H. J., Amemiya H., Wilson C. B., Dixon F. J., Giles G. R., Simpson K. M., Halgrimson C. G. Clotting changes, including disseminated intravascular coagulation, during rapid renal-homograft rejection. N Engl J Med. 1970 Aug 20;283(8):383–390. doi: 10.1056/NEJM197008202830801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Starzl T. E., Lerner R. A., Dixon F. J., Groth C. G., Brettschneider L., Terasaki P. I. Shwartzman reaction after human renal homotransplantation. N Engl J Med. 1968 Mar 21;278(12):642–648. doi: 10.1056/NEJM196803212781202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Steinmuller D., Hart E. A. Passenger leukocytes and induction of allograft immunity. Transplant Proc. 1971 Mar;3(1):673–675. [PubMed] [Google Scholar]
  63. Stewart J. H., Cook K. M., Sharp A. M., Johnston J. M., Sheil A. G., Jeremy D., Bashir H. Tissue matching and early rejection of cadaveric-donor renal allografts: the importance of unidentified donor antigens. Br Med J. 1970 Aug 29;3(5721):487–490. doi: 10.1136/bmj.3.5721.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Stulting R. D., Ward F. E. A computerized system for the selection of organ transplant recipients. Transplantation. 1975 Jan;19(1):27–35. doi: 10.1097/00007890-197501000-00005. [DOI] [PubMed] [Google Scholar]
  65. Tanigaki N., Pressman D. The basic structure and the antigenic characteristics of HL-A antigens. Transplant Rev. 1974;21(0):15–34. doi: 10.1111/j.1600-065x.1974.tb01544.x. [DOI] [PubMed] [Google Scholar]
  66. WILLIAMS M. A., MORTON M., TYLER H. M., DEMPSTER W. J. A BIOCHEMICAL APPROACH TO THE STUDY OF REJECTION OF CANINE RENAL HOMOTRANSPLANTS. II. CHEMICAL ANALYSIS OF KIDNEY HOMOGENATES. Br J Exp Pathol. 1964 Jun;45:235–241. [PMC free article] [PubMed] [Google Scholar]
  67. Williams G. M., DePlanque B., Lower R., Hume D. Antibodies and human transplant rejection. Ann Surg. 1969 Oct;170(4):603–616. doi: 10.1097/00000658-196910000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Williams G. M., Hume D. M., Hudson R. P., Jr, Morris P. J., Kano K., Milgrom F. "Hyperacute" renal-homograft rejection in man. N Engl J Med. 1968 Sep 19;279(12):611–618. doi: 10.1056/NEJM196809192791201. [DOI] [PubMed] [Google Scholar]
  69. van Hooff J. P., van der Steen G. J., Schippers H. M., van Rood J. J. Efficacy of HL-A matching in Eurotransplant. Lancet. 1972 Dec 30;2(7792):1385–1388. doi: 10.1016/s0140-6736(72)92962-5. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES