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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1984 Apr;65(2):267–273.

Study of the target cell of the dengue virus-induced suppressor signal.

M I Shukla, U C Chaturvedi
PMCID: PMC2040952  PMID: 6201186

Abstract

Dengue type 2 virus (DV) induces two generations of T suppressor cells (Ts1 and Ts2) in murine spleen. The Ts2 cells produce a soluble factor ( SF2 ) which suppresses DV-specific IgM antibody plaque-forming cells (PFC). In this study the target cell of SF2 was examined. The results show that SF2 requires a third generation of T cells (T3) in order to mediate suppression. The surface phenotype of this T3 cell is Ly 1+ and the suppression mediated is antigen specific.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cantor H., Boyse E. A. Regulation of cellular and humoral immune responses by T-cell subclasses. Cold Spring Harb Symp Quant Biol. 1977;41(Pt 1):23–32. doi: 10.1101/sqb.1977.041.01.006. [DOI] [PubMed] [Google Scholar]
  2. Cantor H., Gershon R. K. Immunological circuits: cellular composition. Fed Proc. 1979 Jun;38(7):2058–2064. [PubMed] [Google Scholar]
  3. Chaturvedi U. C., Dalakoti H., Mathur A. Characterization of the cytotoxic factor produced in the spleen of dengue virus-infected mice. Immunology. 1980 Oct;41(2):387–392. [PMC free article] [PubMed] [Google Scholar]
  4. Chaturvedi U. C., Shukla M. I. [Characterization of the suppressor factor produced in the spleen of dengue virus-infected mice]. Ann Immunol (Paris) 1981 May-Jun;132C(3):245–255. doi: 10.1016/0769-2625(81)90075-1. [DOI] [PubMed] [Google Scholar]
  5. Chaturvedi U. C., Tandon P., Mathur A., Kumar A. Host defence mechanisms against dengue virus infection of mice. J Gen Virol. 1978 May;39(2):293–302. doi: 10.1099/0022-1317-39-2-293. [DOI] [PubMed] [Google Scholar]
  6. JERNE N. K., NORDIN A. A. Plaque formation in agar by single antibody-producing cells. Science. 1963 Apr 26;140(3565):405–405. [PubMed] [Google Scholar]
  7. Liew F. Y. Regulation of delayed-type hypersensitivity. I. T suppressor cells for delayed-type hypersensitivity to sheep erythrocytes in mice. Eur J Immunol. 1977 Oct;7(10):714–718. doi: 10.1002/eji.1830071013. [DOI] [PubMed] [Google Scholar]
  8. Liew F. Y., Russell S. M. Delayed-type hypersensitivity to influenza virus. Induction of antigen-specific suppressor T cells for delayed-type hypersensitivity to hemagglutinin during influenza virus infection in mice. J Exp Med. 1980 Apr 1;151(4):799–814. doi: 10.1084/jem.151.4.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Liew F. Y., Simpson E. Delayed-type hypersensitivity responses to H-Y: characterization and mapping of Ir genes. Immunogenetics. 1980;11(3):255–266. doi: 10.1007/BF01567792. [DOI] [PubMed] [Google Scholar]
  10. Ramshaw I. A., Bretscher P. A., Parish C. R. Regulation of the immune response. I. Suppression of delayed-type hypersensitivity by T cells from mice expressing humoral immunity. Eur J Immunol. 1976 Oct;6(10):674–679. doi: 10.1002/eji.1830061003. [DOI] [PubMed] [Google Scholar]
  11. Shukla M. I., Chaturvedi U. C. Dengue virus-induced suppressor factor stimulates production of prostaglandin to mediate suppression. J Gen Virol. 1981 Oct;56(Pt 2):241–249. doi: 10.1099/0022-1317-56-2-241. [DOI] [PubMed] [Google Scholar]
  12. Shukla M. I., Chaturvedi U. C. In vivo role of macrophages in transmission of dengue virus-induced suppressor signal to T lymphocytes. Br J Exp Pathol. 1982 Oct;63(5):522–530. [PMC free article] [PubMed] [Google Scholar]
  13. Shukla M. I., Chaturvedi U. C. Transmission of dengue virus-induced suppressor signal from macrophage to lymphocyte occurs by cell contact. Br J Exp Pathol. 1983 Feb;64(1):87–92. [PMC free article] [PubMed] [Google Scholar]
  14. Sy M. S., Nisonoff A., Germain R. N., Benacerraf B., Greene M. I. Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target. J Exp Med. 1981 Jun 1;153(6):1415–1425. doi: 10.1084/jem.153.6.1415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tandon P., Chaturvedi U. C., Mathur A. Dengue virus-induced thymus-derived suppressor cells in the spleen of mice. Immunology. 1979 Dec;38(4):653–658. [PMC free article] [PubMed] [Google Scholar]

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