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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1981 Apr;62(2):200–206.

Gentamicin-induced nephrotoxicity in mice: protection by loop diuretics.

P H Whiting, J Petersen, J G Simpson
PMCID: PMC2041661  PMID: 7236500

Abstract

Gentamicin, at doses of 50 or 100 mg/kg body wt administered daily to healthy male MF1 mice by i.p. injection for either 7 or 10 days caused proximal tubular cell damage shown both by the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and by electron microscopy. The tubular damage was maximal at 7 days. Concomitant administration of any of 3 diuretics-frusemide, bumetanide or piretanide at 5,0.5 and 1 mg/kg body wt/day respectively-resulted in less tubular damage than that caused by gentamicin alone. This finding of protection by diuretics contrasts with those of previous studies of combination gentamicin-diuretic therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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