Abstract
Gentamicin, at doses of 50 or 100 mg/kg body wt administered daily to healthy male MF1 mice by i.p. injection for either 7 or 10 days caused proximal tubular cell damage shown both by the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and by electron microscopy. The tubular damage was maximal at 7 days. Concomitant administration of any of 3 diuretics-frusemide, bumetanide or piretanide at 5,0.5 and 1 mg/kg body wt/day respectively-resulted in less tubular damage than that caused by gentamicin alone. This finding of protection by diuretics contrasts with those of previous studies of combination gentamicin-diuretic therapy.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abramowicz M., Edelmann C. M., Jr Nephrotoxicity of anti-infective drugs. Clin Pediatr (Phila) 1968 Jul;7(7):389–390. doi: 10.1177/000992286800700706. [DOI] [PubMed] [Google Scholar]
- Adelman R. D., Spangler W. L., Beasom F., Ishizaki G., Conzelman G. M. Furosemide enhancement of experimental gentamicin nephrotoxicity: comparison of functional and morphological changes with activities of urinary enzymes. J Infect Dis. 1979 Sep;140(3):342–352. doi: 10.1093/infdis/140.3.342. [DOI] [PubMed] [Google Scholar]
- Bennett W. M., Plamp C. E., Gilbert D. N., Parker R. A., Porter G. A. The influence of dosage regimen on experimental gentamicin nephrotoxicity: dissociation of peak serum levels from renal failure. J Infect Dis. 1979 Oct;140(4):576–580. doi: 10.1093/infdis/140.4.576. [DOI] [PubMed] [Google Scholar]
- Chiu P. J., Long J. F. Effects of hydration on gentamicin excretion and renal accumulation in furosemide-treated rats. Antimicrob Agents Chemother. 1978 Aug;14(2):214–217. doi: 10.1128/aac.14.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Falco F. G., Smith H. M., Arcieri G. M. Nephrotoxicity of aminoglycosides and gentamicin. J Infect Dis. 1969 Apr-May;119(4):406–409. doi: 10.1093/infdis/119.4-5.406. [DOI] [PubMed] [Google Scholar]
- Kosek J. C., Mazze R. I., Cousins M. J. Nephrotoxicity of gentamicin. Lab Invest. 1974 Jan;30(1):48–57. [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Luft F. C., Patel V., Yum M. N., Patel B., Kleit S. A. Experimental aminoglycoside nephrotoxicity. J Lab Clin Med. 1975 Aug;86(2):213–220. [PubMed] [Google Scholar]
- Noël P., Levy V. G. Toxicité rénale de l'association gentamicine-furosémide. Une observation. Nouv Presse Med. 1978 Feb 4;7(5):351–353. [PubMed] [Google Scholar]
- Top F. H., Jr, Grossman R. A., Bartelloni P. J., Segal H. E., Dudding B. A., Russell P. K., Buescher E. L. Immunization with live types 7 and 4 adenovirus vaccines. I. Safety, infectivity, antigenicity, and potency of adenovirus type 7 vaccine in humans. J Infect Dis. 1971 Aug;124(2):148–154. doi: 10.1093/infdis/124.2.148. [DOI] [PubMed] [Google Scholar]
- Wellwood J. M., Ellis B. G., Hall J. H., Robinson D. R., Thompson A. E. Early warning of rejection? Br Med J. 1973 May 5;2(5861):261–265. doi: 10.1136/bmj.2.5861.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wellwood J. M., Lovell D., Thompson A. E., Tighe J. R. Renal damage caused by gentamicin: a study of the effects on renal morphology and urinary enzyme excretion. J Pathol. 1976 Mar;118(3):171–182. doi: 10.1002/path.1711180307. [DOI] [PubMed] [Google Scholar]
- Whiting P. H., Ross I. S., Borthwick L. Serum and urine N-acetyl-beta-D-glucosaminidase in diabetics on diagnosis and subsequent treatment, and stable insulin dependent diabetics. Clin Chim Acta. 1979 Mar 15;92(3):459–463. doi: 10.1016/0009-8981(79)90227-4. [DOI] [PubMed] [Google Scholar]