Abstract
1 Intracerebroventricular administration of diazepam or midazolam decreased the antinociceptive effect of morphine in rats as measured by the "tail flick" method. 2 Midazolam, injected into the periaqueductal grey matter (PAG) antagonized the analgesic effect of morphine. The action of midazolam was partially reversed by bicuculline. 3 These findings support the view that the effect of benzodiazephines on morphine antinociception may be mediated through gamma-aminobutyric acid receptors.
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- Altaffer F. B., Verster F. S., Hall S., Long C. J., D'encarnacao P. A simple and inexpensive cannula technique for chemical stimulation of the brain. Physiol Behav. 1970 Jan;5(1):119–121. doi: 10.1016/0031-9384(70)90022-3. [DOI] [PubMed] [Google Scholar]
- Belin M. F., Aguera M., Tappaz M., McRae-Degueurce A., Bobillier P., Pujol J. F. GABA-accumulating neurons in the nucleus raphe dorsalis and periaqueductal gray in the rat: a biochemical and radioautographic study. Brain Res. 1979 Jul 13;170(2):279–297. doi: 10.1016/0006-8993(79)90107-0. [DOI] [PubMed] [Google Scholar]
- Biggio G., Bella D. D., Frigeni V., Guidotti A. Potentiation of morphine analgesia by muscimol. Neuropharmacology. 1977 Feb;16(2):149–150. doi: 10.1016/0028-3908(77)90063-6. [DOI] [PubMed] [Google Scholar]
- Costa E., Guidotti A. Molecular mechanisms in the receptor action of benzodiazepines. Annu Rev Pharmacol Toxicol. 1979;19:531–545. doi: 10.1146/annurev.pa.19.040179.002531. [DOI] [PubMed] [Google Scholar]
- Fennessy M. R., Sawynok J. The effect of benzodiazepines on the analgesic effect of morphine and sodium salicylate. Arch Int Pharmacodyn Ther. 1973 Jul;204(1):77–85. [PubMed] [Google Scholar]
- GUPTA S. K., GAITONDE B. B. ANALGESIC ACTIVITY OF A NEW QUINOLINE DERIVATIVE, RO--4--1778. Indian J Physiol Pharmacol. 1964 Jan;8:27–32. [PubMed] [Google Scholar]
- Gluckman M. I. Pharmacology of oxazepam (Serax), a new anti-anxiety agent. Curr Ther Res Clin Exp. 1965 Nov;7(11):721–740. [PubMed] [Google Scholar]
- Ho I. K., Loh H. H., Way E. L. Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence. Life Sci. 1976 May 15;18(10):1111–1123. doi: 10.1016/0024-3205(76)90146-6. [DOI] [PubMed] [Google Scholar]
- Mantegazza P., Tammiso R., Vicentini L., Zambotti F., Zonta N. Muscimol antagonism of morphine analgesia in rats. Br J Pharmacol. 1979 Sep;67(1):103–107. [PMC free article] [PubMed] [Google Scholar]
- Ohtsuki K., Nakamura M., Koike T., Ishida N., Baron S. A ribosomal protein mediates eIF-2 phosphorylation by interferon-induced kinase. Nature. 1980 Sep 4;287(5777):65–67. doi: 10.1038/287065a0. [DOI] [PubMed] [Google Scholar]
- Pierson A. K. Assays for narcotic antagonist activity in rodents. Adv Biochem Psychopharmacol. 1973;8(0):245–261. [PubMed] [Google Scholar]
- Randall L. O., Scheckel C. L., Pool W. Pharmacology of medazepam and metabolites. Arch Int Pharmacodyn Ther. 1970 May;185(1):135–148. [PubMed] [Google Scholar]
- Shannon H. E., Holtzman S. G., Davis D. C. Interactions between narcotic analgesics and benzodiazepine derivatives on behavior in the mouse. J Pharmacol Exp Ther. 1976 Nov;199(2):389–399. [PubMed] [Google Scholar]
- Waddington J. L. Behavioural evidence for GABAergic activity of the benzodiazepine flurazepam. Eur J Pharmacol. 1978 Oct 15;51(4):417–422. doi: 10.1016/0014-2999(78)90433-8. [DOI] [PubMed] [Google Scholar]
- Weis J. Morphine antagonistic effect of chlordiazepoxide (Librium). Experientia. 1969 Apr 15;25(4):381–381. doi: 10.1007/BF01899932. [DOI] [PubMed] [Google Scholar]
- Yaksh T. L., Plant R. L., Rudy T. A. Studies on the antagonism by raphe lesions of the antinociceptive action of systemic morphine. Eur J Pharmacol. 1977 Feb 21;41(4):399–408. doi: 10.1016/0014-2999(77)90260-6. [DOI] [PubMed] [Google Scholar]
- Yoneda Y., Takashima S., Kuriyama K. Possible involvement of GABA in morphine analgesia. Biochem Pharmacol. 1976 Dec 1;25(23):2669–2670. doi: 10.1016/0006-2952(76)90525-6. [DOI] [PubMed] [Google Scholar]
- Zonta N., Zambotti F., Vicentini L., Tammiso R., Mantegazza P. Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and beta-endorphin in rats. Naunyn Schmiedebergs Arch Pharmacol. 1981 Jun;316(3):231–234. doi: 10.1007/BF00505654. [DOI] [PubMed] [Google Scholar]