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. 1982 Apr;75(4):569–572. doi: 10.1111/j.1476-5381.1982.tb09175.x

Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam.

P Mantegazza, M Parenti, R Tammiso, P Vita, F Zambotti, N Zonta
PMCID: PMC2071525  PMID: 6121598

Abstract

1 Intracerebroventricular administration of diazepam or midazolam decreased the antinociceptive effect of morphine in rats as measured by the "tail flick" method. 2 Midazolam, injected into the periaqueductal grey matter (PAG) antagonized the analgesic effect of morphine. The action of midazolam was partially reversed by bicuculline. 3 These findings support the view that the effect of benzodiazephines on morphine antinociception may be mediated through gamma-aminobutyric acid receptors.

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Selected References

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