Abstract
Slight modifications of a small, plastic covered greenhouse provided a chamber for the exposure of cattle of all ages to aerosols of foot-and-mouth disease virus. Particle size distributions of aerosols were 76% less than 3 microns, 17% 3-6 microns, and 7% greater than 6 microns immediately after the deVilbis no. 40 nebulizer used was turned off and 90% less than 3 microns, 8% 3-6 microns, and 2% greater than 6 microns 20-30 min later. Pharyngeal virus growth curves and viremia patterns correlated well with the dose of virus to which test cattle were exposed and were similar to those of cattle inoculated intranasally.
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- BEARD C. W., EASTERDAY B. C. AN AEROSOL APPARATUS FOR THE EXPOSURE OF LARGE AND SMALL ANIMALS: DESCRIPTION AND OPERATING CHARACTERISTICS. Am J Vet Res. 1965 Jan;26:174–182. [PubMed] [Google Scholar]
- Barlow D. F. The aerosol stability of a strain of foot-and-mouth disease virus and the effects on stability of precipitation with ammonium sulphate, methanol or polyethylene glycol. J Gen Virol. 1972 Apr;15(1):17–24. doi: 10.1099/0022-1317-15-1-17. [DOI] [PubMed] [Google Scholar]
- Donaldson A. I. The influence of relative humidity on the aerosol stability of different strains of foot-and-mouth disease virus suspended in saliva. J Gen Virol. 1972 Apr;15(1):25–33. doi: 10.1099/0022-1317-15-1-25. [DOI] [PubMed] [Google Scholar]
- Graves J. H., McVicar J. W., Sutmoller P., Trautman R. Contact transmission of foot-and-mouth disease from infected to susceptible cattle. J Infect Dis. 1971 Apr;123(4):386–391. doi: 10.1093/infdis/123.4.386. [DOI] [PubMed] [Google Scholar]
- HATCH T. F. Distribution and deposition of inhaled particles in respiratory tract. Bacteriol Rev. 1961 Sep;25:237–240. doi: 10.1128/br.25.3.237-240.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HENDERSON D. W. An apparatus for the study of airborne infection. J Hyg (Lond) 1952 Mar;50(1):53–68. doi: 10.1017/s0022172400019422. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HYSLOP N. S. AIRBORNE INFECTION WITH THE VIRUS OF FOOT-AND-MOUTH DISEASE. J Comp Pathol. 1965 Apr;75:119–126. doi: 10.1016/0021-9975(65)90002-2. [DOI] [PubMed] [Google Scholar]
- Jericho K. W., O'Connell D. C. Deposition in the respiratory tract of cattle of spores of Bacillus subtilis var niger by inhalation and by nasal instillation. Can J Comp Med. 1974 Jul;38(3):260–265. [PMC free article] [PubMed] [Google Scholar]
- Knight V. Viruses as agents of airborne contagion. Ann N Y Acad Sci. 1980;353:147–156. doi: 10.1111/j.1749-6632.1980.tb18917.x. [DOI] [PubMed] [Google Scholar]
- Larson E. W., Young H. W., Walker J. S. Aerosol evaluations of the DeVilbiss No. 40 and Vaponefrin nebulizers. Appl Environ Microbiol. 1976 Jan;31(1):150–151. doi: 10.1128/aem.31.1.150-151.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lillie L. E., Thomson R. G. The pulmonary clearance of bacteria by calves and mice. Can J Comp Med. 1972 Apr;36(2):129–137. [PMC free article] [PubMed] [Google Scholar]
- Lincoln R. E., Hodges D. R., Klein F., Mahlandt B. G., Jones W. I., Jr, Haines B. W., Rhian M. A., Walker J. S. Role of the lymphatics in the pathogenesis of anthrax. J Infect Dis. 1965 Dec;115(5):481–494. doi: 10.1093/infdis/115.5.481. [DOI] [PubMed] [Google Scholar]
- May K. R. Multistage liquid impinger. Bacteriol Rev. 1966 Sep;30(3):559–570. doi: 10.1128/br.30.3.559-570.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKercher P. D., Dellers R. W., Giordano A. R. Foot-and-mouth disease infection in cattle housed in an isolation unit. Cornell Vet. 1966 Jul;56(3):395–401. [PubMed] [Google Scholar]
- McVicar J. W., Sutmoller P. Growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculation. J Hyg (Lond) 1976 Jun;76(3):467–481. doi: 10.1017/s0022172400055406. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morrow P. E. Physics of airborne particles and their deposition in the lung. Ann N Y Acad Sci. 1980;353:71–80. doi: 10.1111/j.1749-6632.1980.tb18908.x. [DOI] [PubMed] [Google Scholar]
- PALMER F., KINGSBURY S. S. Particle size in nebulized aerosols. Am J Pharm Sci Support Public Health. 1952 Apr;124(4):112–124. [PubMed] [Google Scholar]
- Sellers R. F., Donaldson A. I., Herniman K. A. Ihalation, persistence and dispersal f foot-and-mouth disease virus by man. J Hyg (Lond) 1970 Dec;68(4):565–573. doi: 10.1017/s0022172400042492. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sellers R. F., Herniman K. A., Donaldson A. I. The effects of killing or removal of animals affected with foot-and-mouth disease on the amounts of airborne virus present in looseboxes. Br Vet J. 1971 Aug;127(8):358–365. doi: 10.1016/s0007-1935(17)37440-7. [DOI] [PubMed] [Google Scholar]
- Sellers R. F., Herniman K. A., Gumm I. D. The airborne dispersal of foot-and-mouth disease virus from vaccinated and recovered pigs, cattle and sheep after exposure to infection. Res Vet Sci. 1977 Jul;23(1):70–75. [PubMed] [Google Scholar]
- Sellers R. F., Herniman K. A. The effects of spraying on the amounts of airborne foot-and-mouth disease virus present in loose-boxes. J Hyg (Lond) 1972 Sep;70(3):551–556. doi: 10.1017/s0022172400063130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sellers R. F., Parker J. Airborne excretion of foot-and-mouth disease virus. J Hyg (Lond) 1969 Dec;67(4):671–677. doi: 10.1017/s0022172400042121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sutmoller P., McVicar J. W. Pathogenesis of foot-and-mouth disease: clearance of the virus from the circulation of cattle and goats during experimental viraemia. J Hyg (Lond) 1976 Oct;77(2):245–253. doi: 10.1017/s0022172400024670. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sutmoller P., McVicar J. W. Pathogenesis of foot-and-mouth disease: the lung as an additional portal of entry of the virus. J Hyg (Lond) 1976 Oct;77(2):235–243. doi: 10.1017/s0022172400024669. [DOI] [PMC free article] [PubMed] [Google Scholar]