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. 1969 Dec;64(4):1211–1216. doi: 10.1073/pnas.64.4.1211

AM(1), THE FIRST GENETIC MARKER OF HUMAN IMMUNOGLOBULIN A*

G N Vyas 1, H H Fudenberg 1
PMCID: PMC223270  PMID: 4195395

Abstract

The genetic markers of human immunoglobulins have significantly contributed to the understanding of the molecular biology of antibody synthesis. Like the Gm markers of IgG, the first genetic marker of serum IgA, a major immunoglubulin of exocrine secretions, has now been defined and termed Am(1). It is inherited as a Mendelian dominant trait and is independent of the Gm and Inv allotypes. Am(1) is localized in the α-chains of the γA2 subclass and is independent of the serum γA2 levels. Its polymorphism makes it suitable for studies in population genetics and the molecular biology of IgA globulin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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