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. 1989 Jul;60(1):59–63. doi: 10.1038/bjc.1989.220

Polyclonal origin of mouse skin papillomas.

D J Winton 1, M A Blount 1, B A Ponder 1
PMCID: PMC2247333  PMID: 2803917

Abstract

We show that, from the earliest morphologically recognisable stages of development, mouse skin papillomas induced by a chemical initiation-promotion regime are polyclonal. We have demonstrated polyclonality directly by immunohistochemical staining of the mosaic cell populations in embryo aggregation chimaeras, a method which removes some of the uncertainties of previous conclusions based on analysis using electrophoretic polymorphisms. The findings may imply that initiation within a single cell and promotion of its clonal descendents is not a sufficient explanation for the origin of these tumours and that interaction between cells of more than one clone is involved.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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